{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kilzheimer A"],"funding":["Bundesministerium für Bildung und Forschung","IZKF-Promotionskolleg Tübingen"],"pagination":["450-461"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9851747"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["32(3)"],"pubmed_abstract":["Nutritional influences have been discussed as potential modulators of Parkinson's disease (PD) pathology through various epidemiological and physiological studies. In animal models, a high-fat diet (HFD) with greater intake of lipid-derived calories leads to accelerated disease onset and progression. The underlying molecular mechanisms of HFD-induced aggravated pathology, however, remain largely unclear. In this study, we aimed to further illuminate the effects of a fat-enriched diet in PD by examining the brainstem and hippocampal transcriptome of alpha-synuclein transgenic mice exposed to a life-long HFD. Investigating individual transcript isoforms, differential gene expression and co-expression clusters, we observed that transcriptional differences between wild-type (WT) and transgenic"],"journal":["Human molecular genetics"],"pubmed_title":["Failure of diet-induced transcriptional adaptations in alpha-synuclein transgenic mice."],"pmcid":["PMC9851747"],"funding_grant_id":["01KU1503"],"pubmed_authors":["Kahle PJ","Schulze-Hentrich JM","Kilzheimer A","Rotermund C","Hentrich T"],"additional_accession":[]},"is_claimable":false,"name":"Failure of diet-induced transcriptional adaptations in alpha-synuclein transgenic mice.","description":"Nutritional influences have been discussed as potential modulators of Parkinson's disease (PD) pathology through various epidemiological and physiological studies. In animal models, a high-fat diet (HFD) with greater intake of lipid-derived calories leads to accelerated disease onset and progression. The underlying molecular mechanisms of HFD-induced aggravated pathology, however, remain largely unclear. In this study, we aimed to further illuminate the effects of a fat-enriched diet in PD by examining the brainstem and hippocampal transcriptome of alpha-synuclein transgenic mice exposed to a life-long HFD. Investigating individual transcript isoforms, differential gene expression and co-expression clusters, we observed that transcriptional differences between wild-type (WT) and transgenic","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2026-05-28T16:46:18.887Z","creation":"2025-04-04T03:42:33.489Z"},"accession":"S-EPMC9851747","cross_references":{"pubmed":["36001352"],"doi":["10.1093/hmg/ddac205"]}}