biostudies-literatureKilzheimer ABundesministerium für Bildung und ForschungIZKF-Promotionskolleg Tübingen450-461https://www.ebi.ac.uk/biostudies/studies/S-EPMC9851747biostudies-literatureUnknown32(3)Nutritional influences have been discussed as potential modulators of Parkinson's disease (PD) pathology through various epidemiological and physiological studies. In animal models, a high-fat diet (HFD) with greater intake of lipid-derived calories leads to accelerated disease onset and progression. The underlying molecular mechanisms of HFD-induced aggravated pathology, however, remain largely unclear. In this study, we aimed to further illuminate the effects of a fat-enriched diet in PD by examining the brainstem and hippocampal transcriptome of alpha-synuclein transgenic mice exposed to a life-long HFD. Investigating individual transcript isoforms, differential gene expression and co-expression clusters, we observed that transcriptional differences between wild-type (WT) and transgenicHuman molecular geneticsFailure of diet-induced transcriptional adaptations in alpha-synuclein transgenic mice.PMC985174701KU1503Kahle PJSchulze-Hentrich JMKilzheimer ARotermund CHentrich TfalseFailure of diet-induced transcriptional adaptations in alpha-synuclein transgenic mice.Nutritional influences have been discussed as potential modulators of Parkinson's disease (PD) pathology through various epidemiological and physiological studies. In animal models, a high-fat diet (HFD) with greater intake of lipid-derived calories leads to accelerated disease onset and progression. The underlying molecular mechanisms of HFD-induced aggravated pathology, however, remain largely unclear. In this study, we aimed to further illuminate the effects of a fat-enriched diet in PD by examining the brainstem and hippocampal transcriptome of alpha-synuclein transgenic mice exposed to a life-long HFD. Investigating individual transcript isoforms, differential gene expression and co-expression clusters, we observed that transcriptional differences between wild-type (WT) and transgenic2023-01-01T00:00:00Z2023 Jan2026-05-28T16:46:18.887Z2025-04-04T03:42:33.489ZS-EPMC98517473600135210.1093/hmg/ddac205