biostudies-literatureRapaport SFNIAID NIH HHSNIMH NIH HHSFoundation for the National Institutes of HealthNINR NIH HHS150-160https://www.ebi.ac.uk/biostudies/studies/S-EPMC9851926biostudies-literatureUnknown27(1)HIV remains a threat to global public health, disproportionately affecting countries across Sub-Saharan Africa. Although treatment and access to care have improved, prevention remains critical to ending new HIV infections by 2030. A variety of prevention strategies exist, yet their effectiveness is difficult to measure and variable due to the nature of the interventions and vulnerability of the intervention during implementation. This systematic review of 51 studies synthesizes data on the implementation and evaluation of evidence-based HIV prevention interventions across Sub-Saharan Africa. Studies were included if they occurred between January 1, 2008, and December 31, 2019, inclusive in Sub-Saharan Africa, were written in English, implemented an HIV prevention intervention in the field,AIDS and behaviorImplementing HIV Prevention in Sub-Saharan Africa: A Systematic Review of Interventions Targeting Systems, Communities, and Individuals.PMC9851926F31 MH128079T32 AI102623R01 MH110358R01 NR016650Award Number R01 MH110358Hahn EViswasam NRyan SLyons CETurpin GBaral SRapaport SFHansoti BPeer ADfalseImplementing HIV Prevention in Sub-Saharan Africa: A Systematic Review of Interventions Targeting Systems, Communities, and Individuals.HIV remains a threat to global public health, disproportionately affecting countries across Sub-Saharan Africa. Although treatment and access to care have improved, prevention remains critical to ending new HIV infections by 2030. A variety of prevention strategies exist, yet their effectiveness is difficult to measure and variable due to the nature of the interventions and vulnerability of the intervention during implementation. This systematic review of 51 studies synthesizes data on the implementation and evaluation of evidence-based HIV prevention interventions across Sub-Saharan Africa. Studies were included if they occurred between January 1, 2008, and December 31, 2019, inclusive in Sub-Saharan Africa, were written in English, implemented an HIV prevention intervention in the field,2023-01-01T00:00:00Z2023 Jan2025-04-21T15:08:37.484Z2025-04-21T15:08:37.484ZS-EPMC98519263591358810.1007/s10461-022-03751-0