biostudies-literatureBarris CTNHLBI NIH HHS268-278https://www.ebi.ac.uk/biostudies/studies/S-EPMC9851945biostudies-literatureUnknown80(2)Several clinical and large population studies indicate that women are more salt-sensitive than men, yet the precise mechanisms by which the sexually dimorphic onset manifests remains incompletely understood. Here, we evaluate recent epidemiological data and highlight current knowledge from studies investigating sex-specific mechanisms of salt-sensitive blood pressure (SSBP). Emerging evidence indicates that women of all ethnicities are more salt-sensitive than men, at all ages both premenopausal and postmenopausal. However, menopause exacerbates severity and prevalence of SSBP, suggesting that female sex chromosomes predispose to and female sex hormones mitigate SSBP. Results from both human and rodent studies support the contribution of enhanced and inappropriate activation of the aldosteHypertension (Dallas, Tex. : 1979)Salt Sensitivity of Blood Pressure in Women.PMC9851945R00 HL146948R01 HL130301R01 HL155265F31 HL168963R01 HL147639T32 HL155011Faulkner JLBelin de Chantemele EJBarris CTfalseSalt Sensitivity of Blood Pressure in Women.Several clinical and large population studies indicate that women are more salt-sensitive than men, yet the precise mechanisms by which the sexually dimorphic onset manifests remains incompletely understood. Here, we evaluate recent epidemiological data and highlight current knowledge from studies investigating sex-specific mechanisms of salt-sensitive blood pressure (SSBP). Emerging evidence indicates that women of all ethnicities are more salt-sensitive than men, at all ages both premenopausal and postmenopausal. However, menopause exacerbates severity and prevalence of SSBP, suggesting that female sex chromosomes predispose to and female sex hormones mitigate SSBP. Results from both human and rodent studies support the contribution of enhanced and inappropriate activation of the aldoste2023-01-01T00:00:00Z2023 Feb2025-04-26T11:48:32.309Z2025-02-19T04:59:42.976ZS-EPMC98519453599702410.1161/hypertensionaha.122.1795210.1161/HYPERTENSIONAHA.122.17952