{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Toledano S"],"funding":["Israel Science Foundation"],"pagination":["41"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9852426"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["The semaphorin guidance factors receptor plexin-A2 transduces sema6A and sema6B signals and may mediate, along with plexin-A4, the anti-angiogenic effects of sema6A. When associated with neuropilins plexin-A2 also transduces the anti-angiogenic signals of sema3B. Here we show that inhibition of plexin-A2 expression in glioblastoma derived cells that express wild type p53 such as U87MG and A172 cells, or in primary human endothelial cells, strongly inhibits cell proliferation. Inhibition of plexin-A2 expression in U87MG cells also results in strong inhibition of their tumor forming ability. Knock-out of the plexin-A2 gene in U87MG cells using CRISPR/Cas9 inhibits cell proliferation which is rescued following plexin-A2 re-expression, or expression of a truncated plexin-A2 lacking its extrace"],"journal":["Cell death & disease"],"pubmed_title":["Plexin-A2 enables the proliferation and the development of tumors from glioblastoma derived cells."],"pmcid":["PMC9852426"],"funding_grant_id":["188/16"],"pubmed_authors":["Kessler O","Neufeld G","Sabag AD","Liburkin-Dan T","Toledano S","Ilan N"],"additional_accession":[]},"is_claimable":false,"name":"Plexin-A2 enables the proliferation and the development of tumors from glioblastoma derived cells.","description":"The semaphorin guidance factors receptor plexin-A2 transduces sema6A and sema6B signals and may mediate, along with plexin-A4, the anti-angiogenic effects of sema6A. When associated with neuropilins plexin-A2 also transduces the anti-angiogenic signals of sema3B. Here we show that inhibition of plexin-A2 expression in glioblastoma derived cells that express wild type p53 such as U87MG and A172 cells, or in primary human endothelial cells, strongly inhibits cell proliferation. Inhibition of plexin-A2 expression in U87MG cells also results in strong inhibition of their tumor forming ability. Knock-out of the plexin-A2 gene in U87MG cells using CRISPR/Cas9 inhibits cell proliferation which is rescued following plexin-A2 re-expression, or expression of a truncated plexin-A2 lacking its extrace","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2026-05-28T23:02:19.515Z","creation":"2024-10-16T17:14:28.294Z"},"accession":"S-EPMC9852426","cross_references":{"pubmed":["36658114"],"doi":["10.1038/s41419-023-05554-0"]}}