biostudies-literatureUnknown9Wu ZQ<h4>Background</h4>This study aimed to investigate whether visceral adipose tissue index (VATI) is a significant risk factor for the early recurrence (ER) of HBV-related hepatocellular carcinoma (HCC) (≤5 cm) after hepatectomy.<h4>Methods</h4>The recruited cohort patients who were positive for hepatitis B virus, presented with surgically confirmed HCC (≤5 cm) from Army Medical University (internal training cohort: <i>n</i> = 192) and Chongqing Medical University (external validation group: <i>n</i> = 46). We measured VATI, subcutaneous adipose tissue index (SATI) <i>via</i> computed tomography (CT). ER was defined as recurrence within 2 years after hepatectomy. The impact of parameters on outcome after hepatectomy for HCC was analyzed.<h4>Results</h4>Univariate analysis showed that alpha-fetoprotein levels (<i>p</i> = 0.044), body mass index (BMI) (<i>p</i> < 0.001), SATI (<i>p</i> < 0.001), and VATI (<i>p</i> < 0.001) were significantly different between ER and non-ER groups in internal training cohort. Multivariate analysis identified VATI as an independent risk factor for ER (odds ratio = 1.07, 95% confidence interval: 1.047-1.094, <i>p</i> < 0.001), with a AUC of 0.802, based on the cut-off value of VATI, which was divided into high risk (≥37.45 cm²/m²) and low risk (<37.45 cm²/m²) groups. The prognosis of low risk group was significantly higher than that of high risk group (<i>p </i>< 0.001). The AUC value of VATI in external validation group was 0.854.<h4>Conclusion</h4>VATI was an independent risk factor for the ER, and higher VATI was closely related to poor outcomes after hepatectomy for HBV-related HCC (≤5 cm).Frontiers in surgery985168https://www.ebi.ac.uk/biostudies/studies/S-EPMC9852492biostudies-literaturePreoperative prediction of early recurrence of HBV-related hepatocellular carcinoma (≤5 cm) by visceral adipose tissue index.PMC9852492Wu ZQCai PLi XMXiao XXZhang HRLiu CWang JPeng JCheng JfalsePreoperative prediction of early recurrence of HBV-related hepatocellular carcinoma (≤5 cm) by visceral adipose tissue index.<h4>Background</h4>This study aimed to investigate whether visceral adipose tissue index (VATI) is a significant risk factor for the early recurrence (ER) of HBV-related hepatocellular carcinoma (HCC) (≤5 cm) after hepatectomy.<h4>Methods</h4>The recruited cohort patients who were positive for hepatitis B virus, presented with surgically confirmed HCC (≤5 cm) from Army Medical University (internal training cohort: <i>n</i> = 192) and Chongqing Medical University (external validation group: <i>n</i> = 46). We measured VATI, subcutaneous adipose tissue index (SATI) <i>via</i> computed tomography (CT). ER was defined as recurrence within 2 years after hepatectomy. The impact of parameters on outcome after hepatectomy for HCC was analyzed.<h4>Results</h4>Univariate analysis showed that alpha-fetoprotein levels (<i>p</i> = 0.044), body mass index (BMI) (<i>p</i> < 0.001), SATI (<i>p</i> < 0.001), and VATI (<i>p</i> < 0.001) were significantly different between ER and non-ER groups in internal training cohort. Multivariate analysis identified VATI as an independent risk factor for ER (odds ratio = 1.07, 95% confidence interval: 1.047-1.094, <i>p</i> < 0.001), with a AUC of 0.802, based on the cut-off value of VATI, which was divided into high risk (≥37.45 cm²/m²) and low risk (<37.45 cm²/m²) groups. The prognosis of low risk group was significantly higher than that of high risk group (<i>p </i>< 0.001). The AUC value of VATI in external validation group was 0.854.<h4>Conclusion</h4>VATI was an independent risk factor for the ER, and higher VATI was closely related to poor outcomes after hepatectomy for HBV-related HCC (≤5 cm).2022-01-01T00:00:00Z20222025-04-22T01:11:12.628Z2025-04-05T19:50:46.716ZS-EPMC98524923668415510.3389/fsurg.2022.985168