{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Zhang W"],"pubmed_abstract":["<b>Background:</b> Recent studies have identified that transglutaminases (TGMs) are involved in a widespread epigenetic modification in tumorigenesis. However, it remains unclear how transglutaminase 3 (TGM3) affects in pan-cancer. The present study aimed to explore the clinical and prognostic function of TGM3 in pan-cancer as well as to explore the relationship of TGM3 expression with clinical stage, survival rate, prognosis condition, immune infiltration and mutation indicators. <b>Methods:</b> The relevant data of tumors were obtained from The Cancer Genome Atlas (TCGA), TARGET, Cancer Cell Line Encyclopedia (CCLE) and Genotype-Tissue Expression (GTEx) databases. According to the Human Protein Atlas (HPA) and TIMER databases, we evaluated the protein expression levels of TGM3 in differe"],"journal":["Frontiers in genetics"],"pagination":["993438"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9852731"],"repository":["biostudies-literature"],"pubmed_title":["Clinical and immunological characteristics of TGM3 in pan-cancer: A potential prognostic biomarker."],"pmcid":["PMC9852731"],"pubmed_authors":["Zhang W","Deng D","Cao Y","Zhang X","Wu C","Zhou W","Zhou K"],"additional_accession":[]},"is_claimable":false,"name":"Clinical and immunological characteristics of TGM3 in pan-cancer: A potential prognostic biomarker.","description":"<b>Background:</b> Recent studies have identified that transglutaminases (TGMs) are involved in a widespread epigenetic modification in tumorigenesis. However, it remains unclear how transglutaminase 3 (TGM3) affects in pan-cancer. The present study aimed to explore the clinical and prognostic function of TGM3 in pan-cancer as well as to explore the relationship of TGM3 expression with clinical stage, survival rate, prognosis condition, immune infiltration and mutation indicators. <b>Methods:</b> The relevant data of tumors were obtained from The Cancer Genome Atlas (TCGA), TARGET, Cancer Cell Line Encyclopedia (CCLE) and Genotype-Tissue Expression (GTEx) databases. According to the Human Protein Atlas (HPA) and TIMER databases, we evaluated the protein expression levels of TGM3 in differe","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-22T09:04:22.16Z","creation":"2025-04-05T22:51:38.205Z"},"accession":"S-EPMC9852731","cross_references":{"pubmed":["36685895"],"doi":["10.3389/fgene.2022.993438"]}}