biostudies-literatureUnknown13Zhang W<b>Background:</b> Recent studies have identified that transglutaminases (TGMs) are involved in a widespread epigenetic modification in tumorigenesis. However, it remains unclear how transglutaminase 3 (TGM3) affects in pan-cancer. The present study aimed to explore the clinical and prognostic function of TGM3 in pan-cancer as well as to explore the relationship of TGM3 expression with clinical stage, survival rate, prognosis condition, immune infiltration and mutation indicators. <b>Methods:</b> The relevant data of tumors were obtained from The Cancer Genome Atlas (TCGA), TARGET, Cancer Cell Line Encyclopedia (CCLE) and Genotype-Tissue Expression (GTEx) databases. According to the Human Protein Atlas (HPA) and TIMER databases, we evaluated the protein expression levels of TGM3 in differeFrontiers in genetics993438https://www.ebi.ac.uk/biostudies/studies/S-EPMC9852731biostudies-literatureClinical and immunological characteristics of TGM3 in pan-cancer: A potential prognostic biomarker.PMC9852731Zhang WDeng DCao YZhang XWu CZhou WZhou KfalseClinical and immunological characteristics of TGM3 in pan-cancer: A potential prognostic biomarker.<b>Background:</b> Recent studies have identified that transglutaminases (TGMs) are involved in a widespread epigenetic modification in tumorigenesis. However, it remains unclear how transglutaminase 3 (TGM3) affects in pan-cancer. The present study aimed to explore the clinical and prognostic function of TGM3 in pan-cancer as well as to explore the relationship of TGM3 expression with clinical stage, survival rate, prognosis condition, immune infiltration and mutation indicators. <b>Methods:</b> The relevant data of tumors were obtained from The Cancer Genome Atlas (TCGA), TARGET, Cancer Cell Line Encyclopedia (CCLE) and Genotype-Tissue Expression (GTEx) databases. According to the Human Protein Atlas (HPA) and TIMER databases, we evaluated the protein expression levels of TGM3 in differe2022-01-01T00:00:00Z20222025-04-22T09:04:22.16Z2025-04-05T22:51:38.205ZS-EPMC98527313668589510.3389/fgene.2022.993438