{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Burns GL"],"pubmed_abstract":["<h4>Background</h4>Functional dyspepsia is characterised by chronic symptoms of post-prandial distress or epigastric pain not associated with defined structural pathology. Increased peripheral gut-homing T cells have been previously identified in patients. To date, it is unknown if these T cells were antigen-experienced, or if a specific phenotype was associated with FD.<h4>Objective</h4>This study aimed to characterise T cell populations in the blood and duodenal mucosa of FD patients that may be implicated in disease pathophysiology.<h4>Methods</h4>We identified duodenal T cell populations from 23 controls and 49 Rome III FD patients by flow cytometry using a surface marker antibody panel. We also analysed T cell populations in peripheral blood from 37 controls and 61 patients. Where ava"],"journal":["Frontiers in immunology"],"pagination":["1051632"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9852875"],"repository":["biostudies-literature"],"pubmed_title":["Type 2 and type 17 effector cells are increased in the duodenal mucosa but not peripheral blood of patients with functional dyspepsia."],"pmcid":["PMC9852875"],"pubmed_authors":["Bollipo S","Talley NJ","Walker MM","Gan LT","Keely S","Bruce JK","Mathe A","Nair PM","Horvat JC","Burns GL","Potter MDE","Veysey M","Shah A","Foster PS","Minahan K","Fairlie T","Irani MZ","Holtmann G","Cameron R","Naudin C","Foster R","Koloski NA","Powell N"],"additional_accession":[]},"is_claimable":false,"name":"Type 2 and type 17 effector cells are increased in the duodenal mucosa but not peripheral blood of patients with functional dyspepsia.","description":"<h4>Background</h4>Functional dyspepsia is characterised by chronic symptoms of post-prandial distress or epigastric pain not associated with defined structural pathology. Increased peripheral gut-homing T cells have been previously identified in patients. To date, it is unknown if these T cells were antigen-experienced, or if a specific phenotype was associated with FD.<h4>Objective</h4>This study aimed to characterise T cell populations in the blood and duodenal mucosa of FD patients that may be implicated in disease pathophysiology.<h4>Methods</h4>We identified duodenal T cell populations from 23 controls and 49 Rome III FD patients by flow cytometry using a surface marker antibody panel. We also analysed T cell populations in peripheral blood from 37 controls and 61 patients. Where ava","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-26T00:36:23.56Z","creation":"2025-04-06T09:48:45.421Z"},"accession":"S-EPMC9852875","cross_references":{"pubmed":["36685573"],"doi":["10.3389/fimmu.2022.1051632"]}}