biostudies-literatureUnknown13Burns GL<h4>Background</h4>Functional dyspepsia is characterised by chronic symptoms of post-prandial distress or epigastric pain not associated with defined structural pathology. Increased peripheral gut-homing T cells have been previously identified in patients. To date, it is unknown if these T cells were antigen-experienced, or if a specific phenotype was associated with FD.<h4>Objective</h4>This study aimed to characterise T cell populations in the blood and duodenal mucosa of FD patients that may be implicated in disease pathophysiology.<h4>Methods</h4>We identified duodenal T cell populations from 23 controls and 49 Rome III FD patients by flow cytometry using a surface marker antibody panel. We also analysed T cell populations in peripheral blood from 37 controls and 61 patients. Where avaFrontiers in immunology1051632https://www.ebi.ac.uk/biostudies/studies/S-EPMC9852875biostudies-literatureType 2 and type 17 effector cells are increased in the duodenal mucosa but not peripheral blood of patients with functional dyspepsia.PMC9852875Bollipo STalley NJWalker MMGan LTKeely SBruce JKMathe ANair PMHorvat JCBurns GLPotter MDEVeysey MShah AFoster PSMinahan KFairlie TIrani MZHoltmann GCameron RNaudin CFoster RKoloski NAPowell NfalseType 2 and type 17 effector cells are increased in the duodenal mucosa but not peripheral blood of patients with functional dyspepsia.<h4>Background</h4>Functional dyspepsia is characterised by chronic symptoms of post-prandial distress or epigastric pain not associated with defined structural pathology. Increased peripheral gut-homing T cells have been previously identified in patients. To date, it is unknown if these T cells were antigen-experienced, or if a specific phenotype was associated with FD.<h4>Objective</h4>This study aimed to characterise T cell populations in the blood and duodenal mucosa of FD patients that may be implicated in disease pathophysiology.<h4>Methods</h4>We identified duodenal T cell populations from 23 controls and 49 Rome III FD patients by flow cytometry using a surface marker antibody panel. We also analysed T cell populations in peripheral blood from 37 controls and 61 patients. Where ava2022-01-01T00:00:00Z20222025-04-26T00:36:23.56Z2025-04-06T09:48:45.421ZS-EPMC98528753668557310.3389/fimmu.2022.1051632