biostudies-literatureUnknown13Ramirez JLMosquito resistance to microbial infections, including fungal entomopathogens that are selected for mosquito control, depend on a range of antimicrobial effectors, among them antimicrobial peptides (AMPs). These short peptides, along the antimicrobial effector lysozyme, act by disrupting the microbial cell membrane or by interfering with microbial physiological processes. While the induction of AMPs and lysozyme during fungal entomopathogenic infections have been reported, their contribution to the mosquito antifungal response has not been evaluated. In this study, we assessed the induction of <i>Ae. aegypti</i> AMPs and lysozyme genes at two points of infection and against distinct entomopathogenic fungi. Our results indicate that fungal infection elicits the expression of cecropin, defenFrontiers in microbiology1062383https://www.ebi.ac.uk/biostudies/studies/S-EPMC9852974biostudies-literatureMultiple mosquito AMPs are needed to potentiate their antifungal effect against entomopathogenic fungi.PMC9852974Ramirez JLHampton KJRosales AMMuturi EJfalseMultiple mosquito AMPs are needed to potentiate their antifungal effect against entomopathogenic fungi.Mosquito resistance to microbial infections, including fungal entomopathogens that are selected for mosquito control, depend on a range of antimicrobial effectors, among them antimicrobial peptides (AMPs). These short peptides, along the antimicrobial effector lysozyme, act by disrupting the microbial cell membrane or by interfering with microbial physiological processes. While the induction of AMPs and lysozyme during fungal entomopathogenic infections have been reported, their contribution to the mosquito antifungal response has not been evaluated. In this study, we assessed the induction of <i>Ae. aegypti</i> AMPs and lysozyme genes at two points of infection and against distinct entomopathogenic fungi. Our results indicate that fungal infection elicits the expression of cecropin, defen2022-01-01T00:00:00Z20222025-04-04T19:47:53.388Z2025-02-19T03:00:14.487ZS-EPMC98529743668760710.3389/fmicb.2022.1062383