{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Duan X"],"funding":["Natural Science Foundation of Gansu Province"],"pubmed_abstract":["<h4>Objectives</h4>This study aimed to investigate the protective effect of ginsenoside Rg3 (GRg3) against acute radiation proctitis (ARP) in rats.<h4>Methods</h4>Wistar rats were randomly divided into control, model, dexamethasone-positive, GRg3 low-dose, GRg3 medium-dose, and GRg3 high-dose groups. The ARP rat model was established by a single 22-Gy irradiation of 6 MV) X-rays. The distribution and function of intestinal flora were detected using 16S rRNA high-throughput sequencing, rectal tissue was observed by hematoxylin and eosin (H&E) staining, the expression of interleukin 1β (IL-1β) and IL-10 inflammatory factors was detected by ELISA, and mRNA and protein expression of toll-like receptor 4 (TLR4), myeloid differentiation primary response 88 (MyD88), and nuclear factor kappa-light"],"journal":["Frontiers in cellular and infection microbiology"],"pagination":["1028576"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9853003"],"repository":["biostudies-literature"],"pubmed_title":["Ginsenoside Rg3 treats acute radiation proctitis through the TLR4/MyD88/NF-κB pathway and regulation of intestinal flora."],"pmcid":["PMC9853003"],"pubmed_authors":["Cao L","Li X","Hu T","Zeng L","Wang H","Lin L","Duan X","Cai H"],"additional_accession":[]},"is_claimable":false,"name":"Ginsenoside Rg3 treats acute radiation proctitis through the TLR4/MyD88/NF-κB pathway and regulation of intestinal flora.","description":"<h4>Objectives</h4>This study aimed to investigate the protective effect of ginsenoside Rg3 (GRg3) against acute radiation proctitis (ARP) in rats.<h4>Methods</h4>Wistar rats were randomly divided into control, model, dexamethasone-positive, GRg3 low-dose, GRg3 medium-dose, and GRg3 high-dose groups. The ARP rat model was established by a single 22-Gy irradiation of 6 MV) X-rays. The distribution and function of intestinal flora were detected using 16S rRNA high-throughput sequencing, rectal tissue was observed by hematoxylin and eosin (H&E) staining, the expression of interleukin 1β (IL-1β) and IL-10 inflammatory factors was detected by ELISA, and mRNA and protein expression of toll-like receptor 4 (TLR4), myeloid differentiation primary response 88 (MyD88), and nuclear factor kappa-light","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-28T03:41:11.599Z","creation":"2025-02-19T03:00:28.121Z"},"accession":"S-EPMC9853003","cross_references":{"pubmed":["36683687"],"doi":["10.3389/fcimb.2022.1028576"]}}