biostudies-literatureJu CThe Everest Project of Fourth Military Medical UniversityShaanxi Provincial Key R&D ProgramShaanxi Provincial Key R&amp;D ProgramNational Natural Scientific Foundation of ChinaDiscipline Boost Project of the First Affiliated Hospital of Air Force Military Medical University5https://www.ebi.ac.uk/biostudies/studies/S-EPMC9854040biostudies-literatureUnknown28(1)<h4>Background</h4>Secondary spinal cord injury (SCI) often causes the aggravation of inflammatory reaction and nerve injury, which affects the recovery of motor function. Bone-marrow-derived macrophages (BMDMs) were recruited to the injured area after SCI, and the M1 polarization is the key process for inducing inflammatory response and neuronal apoptosis. We previously showed that photobiomodulation (PBM) can inhibit the polarization of M1 phenotype of BMDMs and reduce inflammation, but the underlying mechanisms are unclear. The purpose of this study is to explore the potential target and mechanism of PBM in treating SCI.<h4>Methods</h4>Transcriptome sequencing and bioinformatics analysis showed that long noncoding RNA taurine upregulated gene 1 (lncRNA TUG1) was a potential target of PBCellular & molecular biology lettersPhotobiomodulation promotes spinal cord injury repair by inhibiting macrophage polarization through lncRNA TUG1-miR-1192/TLR3 axis.PMC9854040NO.2020ZDLSF02-052018RCFC02XJZT19Z22NO.2021ZDLSF02-10NO.81572151NO.81070996XJZT21L01Li XZhu ZZhang ZDing TZuo XLiang ZHu XMa YWang XJu CWang ZSong ZfalsePhotobiomodulation promotes spinal cord injury repair by inhibiting macrophage polarization through lncRNA TUG1-miR-1192/TLR3 axis.<h4>Background</h4>Secondary spinal cord injury (SCI) often causes the aggravation of inflammatory reaction and nerve injury, which affects the recovery of motor function. Bone-marrow-derived macrophages (BMDMs) were recruited to the injured area after SCI, and the M1 polarization is the key process for inducing inflammatory response and neuronal apoptosis. We previously showed that photobiomodulation (PBM) can inhibit the polarization of M1 phenotype of BMDMs and reduce inflammation, but the underlying mechanisms are unclear. The purpose of this study is to explore the potential target and mechanism of PBM in treating SCI.<h4>Methods</h4>Transcriptome sequencing and bioinformatics analysis showed that long noncoding RNA taurine upregulated gene 1 (lncRNA TUG1) was a potential target of PB2023-01-01T00:00:00Z2023 Jan2026-06-21T03:18:55.662Z2025-02-19T01:08:19.291ZS-EPMC98540403665847810.1186/s11658-023-00417-0