{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Prinz J"],"funding":["Monique Dornonville de la Cour Foundation","Wolfermann-Naegeli Foundation"],"pagination":["118"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9854686"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["Periprosthetic joint infections (PJI) are difficult to treat due to biofilm formation on implant surfaces, often requiring removal or exchange of prostheses along with long-lasting antibiotic treatment. This in vitro study investigated the effect of methylene blue photodynamic therapy (MB-PDT) on PJI-causing biofilms on different implant materials. MB-PDT (664 nm LED, 15 J/cm<sup>2</sup>) was tested on different <i>Staphylococcus aureus, Staphylococcus epidermidis</i>, <i>Escherichia coli</i> and <i>Cutibacterium acnes</i> strains in both planktonic form and grown in early and mature biofilms on prosthetic materials (polyethylene, titanium alloys, cobalt-chrome-based alloys, and bone cement). The minimum bactericidal concentration with 100% killing (MBC<sub>100%</sub>) was determined. Chem"],"journal":["Antibiotics (Basel, Switzerland)"],"pubmed_title":["Effective Biofilm Eradication on Orthopedic Implants with Methylene Blue Based Antimicrobial Photodynamic Therapy In Vitro."],"pmcid":["PMC9854686"],"funding_grant_id":["na"],"pubmed_authors":["Grob MC","Walt H","Neuhaus S","Prinz J","Wink M","Bosshard PP","Achermann Y"],"additional_accession":[]},"is_claimable":false,"name":"Effective Biofilm Eradication on Orthopedic Implants with Methylene Blue Based Antimicrobial Photodynamic Therapy In Vitro.","description":"Periprosthetic joint infections (PJI) are difficult to treat due to biofilm formation on implant surfaces, often requiring removal or exchange of prostheses along with long-lasting antibiotic treatment. This in vitro study investigated the effect of methylene blue photodynamic therapy (MB-PDT) on PJI-causing biofilms on different implant materials. MB-PDT (664 nm LED, 15 J/cm<sup>2</sup>) was tested on different <i>Staphylococcus aureus, Staphylococcus epidermidis</i>, <i>Escherichia coli</i> and <i>Cutibacterium acnes</i> strains in both planktonic form and grown in early and mature biofilms on prosthetic materials (polyethylene, titanium alloys, cobalt-chrome-based alloys, and bone cement). The minimum bactericidal concentration with 100% killing (MBC<sub>100%</sub>) was determined. Chem","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-04T11:33:18.922Z","creation":"2025-04-04T11:33:18.922Z"},"accession":"S-EPMC9854686","cross_references":{"pubmed":["36671319"],"doi":["10.3390/antibiotics12010118"]}}