biostudies-literatureUnknown12(1)Cheng MJIn our continued search for bioactive metabolites from cultures of rare Actinobacteria resources from all over Taiwan and various natural ecological environments, an active antimicrobial strain of Acrocarpospora punica 04107M was collected in Taitung County in Taiwan and prepared from soil. The bioassay-guided fractionation of the BuOH extract of a culture broth from A. punica 04107M led to the isolation of five previously undescribed compounds: Acrocarposporins A-E (Compounds 1-5). All the constituents were confirmed by HRESIMS and 1D- and 2D-NMR spectroscopy. Their antifungal activity was also evaluated. Our results showed that four constituents (Compounds 1, 2, 4, and 5) possessed mild antifungal activity against AAntibiotics (Basel, Switzerland)95https://www.ebi.ac.uk/biostudies/studies/S-EPMC9854854biostudies-literatureAntifungal Activities of Compounds Produced by Newly Isolated Acrocarpospora Strains.PMC9854854Wu MDLeu JYTseng MCheng MJChen JJfalseAntifungal Activities of Compounds Produced by Newly Isolated Acrocarpospora Strains.In our continued search for bioactive metabolites from cultures of rare Actinobacteria resources from all over Taiwan and various natural ecological environments, an active antimicrobial strain of Acrocarpospora punica 04107M was collected in Taitung County in Taiwan and prepared from soil. The bioassay-guided fractionation of the BuOH extract of a culture broth from A. punica 04107M led to the isolation of five previously undescribed compounds: Acrocarposporins A-E (Compounds 1-5). All the constituents were confirmed by HRESIMS and 1D- and 2D-NMR spectroscopy. Their antifungal activity was also evaluated. Our results showed that four constituents (Compounds 1, 2, 4, and 5) possessed mild antifungal activity against A2023-01-01T00:00:00Z2023 Jan2025-04-22T01:07:37.02Z2025-04-05T19:49:03.57ZS-EPMC98548543667129610.3390/antibiotics12010095