{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gomez-Bernal F"],"funding":["Instituto de Salud Carlos III"],"pagination":["73"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9855909"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["Transforming growth factor beta (TGF-β) is a highly pleiotropic cytokine that has broad anti-inflammatory and immunosuppressive effects. In patients with systemic lupus erythematosus (SLE), the immunosuppressive effect of TGF-β1 is thought to be dysfunctional. In the present work, we aimed to study the relationship between the serum levels of TGF-β1 with the characteristics of the disease as well as with the patterns of activity, damage, or severity of the disease. Two hundred and eighty-four patients with well-characterized SLE were recruited. The serum levels of TGF-β1 were assessed. A multivariable linear regression analysis was performed to analyze the relation of disease characteristics to TGF-β1. The Katz severity index (beta coefficient 179 [95% confidence interval 7-350] pg/mL, <i>"],"journal":["Biomolecules"],"pubmed_title":["Serum Levels of Transforming Growth Factor Beta 1 in Systemic Lupus Erythematosus Patients."],"pmcid":["PMC9855909"],"funding_grant_id":["PI20/00084"],"pubmed_authors":["Quevedo-Abeledo JC","Gonzalez-Gay MA","Garcia-Gonzalez M","Ferraz-Amaro I","Gonzalez-Rivero AF","Fernandez-Cladera Y","Martin-Gonzalez C","Gomez-Bernal F","de Vera-Gonzalez A"],"additional_accession":[]},"is_claimable":false,"name":"Serum Levels of Transforming Growth Factor Beta 1 in Systemic Lupus Erythematosus Patients.","description":"Transforming growth factor beta (TGF-β) is a highly pleiotropic cytokine that has broad anti-inflammatory and immunosuppressive effects. In patients with systemic lupus erythematosus (SLE), the immunosuppressive effect of TGF-β1 is thought to be dysfunctional. In the present work, we aimed to study the relationship between the serum levels of TGF-β1 with the characteristics of the disease as well as with the patterns of activity, damage, or severity of the disease. Two hundred and eighty-four patients with well-characterized SLE were recruited. The serum levels of TGF-β1 were assessed. A multivariable linear regression analysis was performed to analyze the relation of disease characteristics to TGF-β1. The Katz severity index (beta coefficient 179 [95% confidence interval 7-350] pg/mL, <i>","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-04T11:33:34.441Z","creation":"2025-04-04T11:33:34.441Z"},"accession":"S-EPMC9855909","cross_references":{"pubmed":["36671458"],"doi":["10.3390/biom13010073"]}}