biostudies-literatureGomez-Bernal FInstituto de Salud Carlos III73https://www.ebi.ac.uk/biostudies/studies/S-EPMC9855909biostudies-literatureUnknown13(1)Transforming growth factor beta (TGF-β) is a highly pleiotropic cytokine that has broad anti-inflammatory and immunosuppressive effects. In patients with systemic lupus erythematosus (SLE), the immunosuppressive effect of TGF-β1 is thought to be dysfunctional. In the present work, we aimed to study the relationship between the serum levels of TGF-β1 with the characteristics of the disease as well as with the patterns of activity, damage, or severity of the disease. Two hundred and eighty-four patients with well-characterized SLE were recruited. The serum levels of TGF-β1 were assessed. A multivariable linear regression analysis was performed to analyze the relation of disease characteristics to TGF-β1. The Katz severity index (beta coefficient 179 [95% confidence interval 7-350] pg/mL, <i>BiomoleculesSerum Levels of Transforming Growth Factor Beta 1 in Systemic Lupus Erythematosus Patients.PMC9855909PI20/00084Quevedo-Abeledo JCGonzalez-Gay MAGarcia-Gonzalez MFerraz-Amaro IGonzalez-Rivero AFFernandez-Cladera YMartin-Gonzalez CGomez-Bernal Fde Vera-Gonzalez AfalseSerum Levels of Transforming Growth Factor Beta 1 in Systemic Lupus Erythematosus Patients.Transforming growth factor beta (TGF-β) is a highly pleiotropic cytokine that has broad anti-inflammatory and immunosuppressive effects. In patients with systemic lupus erythematosus (SLE), the immunosuppressive effect of TGF-β1 is thought to be dysfunctional. In the present work, we aimed to study the relationship between the serum levels of TGF-β1 with the characteristics of the disease as well as with the patterns of activity, damage, or severity of the disease. Two hundred and eighty-four patients with well-characterized SLE were recruited. The serum levels of TGF-β1 were assessed. A multivariable linear regression analysis was performed to analyze the relation of disease characteristics to TGF-β1. The Katz severity index (beta coefficient 179 [95% confidence interval 7-350] pg/mL, <i>2022-01-01T00:00:00Z2022 Dec2025-04-04T11:33:34.441Z2025-04-04T11:33:34.441ZS-EPMC98559093667145810.3390/biom13010073