biostudies-literatureBanerjee TMissouri State UniversityUnited States Department of AgricultureNIGMS NIH HHS109https://www.ebi.ac.uk/biostudies/studies/S-EPMC9856065biostudies-literatureUnknown13(1)Frequent outbreaks of food-borne pathogens, particularly <i>E. coli</i> O157:H7, continue to impact human health and the agricultural economy tremendously. The required cell count for this pathogenic strain of <i>E. coli</i> O157:H7 is relatively low and hence it is vital to detect at low colony forming unit (CFU) counts. Available detection methods, though sensitive, fall short in terms of timeliness and often require extensive sample processing. To overcome these limitations, we propose a novel magneto-plasmonic nanosensor (MPnS) by integrating surface plasmon resonance (SPR) properties with spin-spin magnetic relaxation (T2 MR) technology. We engineered MPnS by encapsulating several gold nanoparticles (GNPs) within the polymer-coating of iron oxide nanoparticles (IONPs). First, the polyBiosensorsTunable Magneto-Plasmonic Nanosensor for Sensitive Detection of Foodborne Pathogens.PMC9856065P20 GM1034182018-07295StartupPanchal NBanerjee TPatel TKajal KSutton CKoti NElliott RArogunyo ESantra SfalseTunable Magneto-Plasmonic Nanosensor for Sensitive Detection of Foodborne Pathogens.Frequent outbreaks of food-borne pathogens, particularly <i>E. coli</i> O157:H7, continue to impact human health and the agricultural economy tremendously. The required cell count for this pathogenic strain of <i>E. coli</i> O157:H7 is relatively low and hence it is vital to detect at low colony forming unit (CFU) counts. Available detection methods, though sensitive, fall short in terms of timeliness and often require extensive sample processing. To overcome these limitations, we propose a novel magneto-plasmonic nanosensor (MPnS) by integrating surface plasmon resonance (SPR) properties with spin-spin magnetic relaxation (T2 MR) technology. We engineered MPnS by encapsulating several gold nanoparticles (GNPs) within the polymer-coating of iron oxide nanoparticles (IONPs). First, the poly2023-01-01T00:00:00Z2023 Jan2025-04-26T00:36:17.032Z2025-04-06T09:49:47.438ZS-EPMC98560653667194410.3390/bios13010109