{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hue SS"],"funding":["National Medical Research Council"],"pagination":["453"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9856483"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(2)"],"pubmed_abstract":["Accurate diagnosis of the most common histological subtypes of small B-cell lymphomas is challenging due to overlapping morphological features and limitations of ancillary testing, which involves a large number of immunostains and molecular investigations. In addition, a common diagnostic challenge is to distinguish reactive lymphoid hyperplasia that do not require additional stains from such lymphomas that need ancillary investigations. We investigated if tissue-specific microRNA (miRNA) expression may provide potential biomarkers to improve the pathology diagnostic workflow. This study seeks to distinguish reactive lymphoid proliferation (RL) from small B-cell lymphomas, and to further distinguish the four main subtypes of small B-cell lymphomas. Two datasets were included: a discovery c"],"journal":["Cancers"],"pubmed_title":["Tissue-Specific microRNA Expression Profiling to Derive Novel Biomarkers for the Diagnosis and Subtyping of Small B-Cell Lymphomas."],"pmcid":["PMC9856483"],"funding_grant_id":["MOH-OFLCG18May-0004"],"pubmed_authors":["Tang LWT","Ho YH","Hue SS","Tan SY","Bin Masroni MS","Ong DB","Jin Y","Cheng H","Leong SM"],"additional_accession":[]},"is_claimable":false,"name":"Tissue-Specific microRNA Expression Profiling to Derive Novel Biomarkers for the Diagnosis and Subtyping of Small B-Cell Lymphomas.","description":"Accurate diagnosis of the most common histological subtypes of small B-cell lymphomas is challenging due to overlapping morphological features and limitations of ancillary testing, which involves a large number of immunostains and molecular investigations. In addition, a common diagnostic challenge is to distinguish reactive lymphoid hyperplasia that do not require additional stains from such lymphomas that need ancillary investigations. We investigated if tissue-specific microRNA (miRNA) expression may provide potential biomarkers to improve the pathology diagnostic workflow. This study seeks to distinguish reactive lymphoid proliferation (RL) from small B-cell lymphomas, and to further distinguish the four main subtypes of small B-cell lymphomas. Two datasets were included: a discovery c","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-22T01:07:01.041Z","creation":"2025-04-05T19:52:22.083Z"},"accession":"S-EPMC9856483","cross_references":{"pubmed":["36672402"],"doi":["10.3390/cancers15020453"]}}