{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(2)"],"submitter":["Sfakianaki M"],"pubmed_abstract":["MMR gene germline mutations are considered a major genetic disorder in patients with hereditary nonpolyposis colon cancer (HNPCC) or Lynch syndrome; A total of 15% of sporadic colon carcinomas are MSI-High. MSI has also been observed in other cancers, such as endometrial, gastric, and ovarian cancer. The aim of the current study was to correlate and outline the optimal method between the molecular testing of the instability of microsatellite DNA regions (MSI status) and the loss of protein expression by immunehistochemistry (MMR). A total of 242 paraffin-embedded tissues from gastrointestinal, gynecological, genitourinary, lung, breast, and unknown primary cancer patients were analyzed for the expression of <i>MLH1</i>/<i>MSH2</i>/<i>MSH6</i>/<i>PMS2</i> by immunohistochemistry, as well as"],"journal":["Cancers"],"pagination":["353"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9856558"],"repository":["biostudies-literature"],"pubmed_title":["Evaluation of Microsatellite Instability Molecular Analysis versus Immuno-Histochemical Interpretation in Malignant Neoplasms with Different Localizations."],"pmcid":["PMC9856558"],"pubmed_authors":["Mavroudis D","Tsantaki K","Datseri G","Messaritakis I","Koutoulaki C","Moustou E","Souglakos J","Sfakianaki M","Tzardi M"],"additional_accession":[]},"is_claimable":false,"name":"Evaluation of Microsatellite Instability Molecular Analysis versus Immuno-Histochemical Interpretation in Malignant Neoplasms with Different Localizations.","description":"MMR gene germline mutations are considered a major genetic disorder in patients with hereditary nonpolyposis colon cancer (HNPCC) or Lynch syndrome; A total of 15% of sporadic colon carcinomas are MSI-High. MSI has also been observed in other cancers, such as endometrial, gastric, and ovarian cancer. The aim of the current study was to correlate and outline the optimal method between the molecular testing of the instability of microsatellite DNA regions (MSI status) and the loss of protein expression by immunehistochemistry (MMR). A total of 242 paraffin-embedded tissues from gastrointestinal, gynecological, genitourinary, lung, breast, and unknown primary cancer patients were analyzed for the expression of <i>MLH1</i>/<i>MSH2</i>/<i>MSH6</i>/<i>PMS2</i> by immunohistochemistry, as well as","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-06T09:49:27.511Z","creation":"2025-04-06T09:49:27.511Z"},"accession":"S-EPMC9856558","cross_references":{"pubmed":["36672302"],"doi":["10.3390/cancers15020353"]}}