{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sridharan V"],"funding":["United States Department of Homeland Security","NIGMS NIH HHS"],"pagination":["406"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9856613"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(2)"],"pubmed_abstract":["In radiation therapy of tumors in the chest, such as in lung or esophageal cancer, part of the heart may be situated in the radiation field. This can lead to the development of radiation-induced heart disease. The mechanisms by which radiation causes long-term injury to the heart are not fully understood, but investigations in pre-clinical research models can contribute to mechanistic insights. Recent developments in X-ray technology have enabled partial heart irradiation in mouse models. In this study, adult male and female C57BL/6J mice were exposed to whole heart (a single dose of 8 or 16 Gy) and partial heart irradiation (16 Gy to 40% of the heart). Plasma samples were collected at 5 days and 2 weeks after the irradiation for metabolomics analysis, and the cardiac collagen deposition, "],"journal":["Cancers"],"pubmed_title":["Effects of Whole and Partial Heart Irradiation on Collagen, Mast Cells, and Toll-like Receptor 4 in the Mouse Heart."],"pmcid":["PMC9856613"],"funding_grant_id":["P20 GM109005","W81XWH1910737"],"pubmed_authors":["Krager KJ","Sridharan V","Pawar SA","Li Y","Bansal S","Cheema AK","Boerma M"],"additional_accession":[]},"is_claimable":false,"name":"Effects of Whole and Partial Heart Irradiation on Collagen, Mast Cells, and Toll-like Receptor 4 in the Mouse Heart.","description":"In radiation therapy of tumors in the chest, such as in lung or esophageal cancer, part of the heart may be situated in the radiation field. This can lead to the development of radiation-induced heart disease. The mechanisms by which radiation causes long-term injury to the heart are not fully understood, but investigations in pre-clinical research models can contribute to mechanistic insights. Recent developments in X-ray technology have enabled partial heart irradiation in mouse models. In this study, adult male and female C57BL/6J mice were exposed to whole heart (a single dose of 8 or 16 Gy) and partial heart irradiation (16 Gy to 40% of the heart). Plasma samples were collected at 5 days and 2 weeks after the irradiation for metabolomics analysis, and the cardiac collagen deposition, ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-04T14:27:32.337Z","creation":"2025-04-04T14:27:32.337Z"},"accession":"S-EPMC9856613","cross_references":{"pubmed":["36672353"],"doi":["10.3390/cancers15020406"]}}