biostudies-literatureZhu JNIDDK NIH HHSNHLBI NIH HHSe2250621https://www.ebi.ac.uk/biostudies/studies/S-EPMC9856626biostudies-literatureUnknown6(1)<h4>Importance</h4>The associations of B vitamin status with metabolic syndrome (MetS) incidence among the US population remain unclear.<h4>Objective</h4>To investigate intakes and serum concentrations of folate, vitamin B6, and vitamin B12 in association with MetS risk in a large US cohort.<h4>Design, setting, and participants</h4>This prospective study included Black and White young adults in the US who were enrolled from 1985 to 1986 and studied until 2015 to 2016. Diet was assessed using a validated diet history at examination years 0, 7, and 20. Serum concentrations of folate, vitamin B6, and vitamin B12 were assayed at examination years 0, 7, and 15 in a subset of 1430 participants. MetS was ascertained by clinic and laboratory measurements and self-reported medication use. Data wereJAMA network openFolate, Vitamin B6, and Vitamin B12 Status in Association With Metabolic Syndrome Incidence.PMC9856626HHSN268201800005IHHSN268201800004IHHSN268201800007IHHSN268201800006IR01 DK116603HHSN268201800003IShikany JMLu LZhu JChen CKahe KD'Alton MEfalseFolate, Vitamin B6, and Vitamin B12 Status in Association With Metabolic Syndrome Incidence.<h4>Importance</h4>The associations of B vitamin status with metabolic syndrome (MetS) incidence among the US population remain unclear.<h4>Objective</h4>To investigate intakes and serum concentrations of folate, vitamin B6, and vitamin B12 in association with MetS risk in a large US cohort.<h4>Design, setting, and participants</h4>This prospective study included Black and White young adults in the US who were enrolled from 1985 to 1986 and studied until 2015 to 2016. Diet was assessed using a validated diet history at examination years 0, 7, and 20. Serum concentrations of folate, vitamin B6, and vitamin B12 were assayed at examination years 0, 7, and 15 in a subset of 1430 participants. MetS was ascertained by clinic and laboratory measurements and self-reported medication use. Data were2023-01-01T00:00:00Z2023 Jan2026-07-16T20:12:03.957Z2025-04-06T02:21:35.673ZS-EPMC98566263663013410.1001/jamanetworkopen.2022.50621