{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wells C"],"funding":["São Paulo Research Foundation","National Council for Scientific and Technological Development","Wellcome Trust","Genome Canada","NIH HHS"],"pagination":["287"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9856672"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(2)"],"pubmed_abstract":["The serine/threonine protein kinase calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) plays critical roles in a range of biological processes. Despite its importance, only a handful of inhibitors of CAMKK2 have been disclosed. Having a selective small molecule tool to interrogate this kinase will help demonstrate that CAMKK2 inhibition can be therapeutically beneficial. Herein, we disclose SGC-CAMKK2-1, a selective chemical probe that targets CAMKK2."],"journal":["Cells"],"pubmed_title":["SGC-CAMKK2-1: A Chemical Probe for CAMKK2."],"pmcid":["PMC9856672"],"funding_grant_id":["2014/50897-0","465651/2014-3","106169/ZZ14/Z","106169","1U24DK116204-01","R01CA218442","2013/50724-5","115766","NIH R01CA184208"],"pubmed_authors":["Stork B","Scott JW","Catta-Preta CMC","Racioppi L","Liang Y","Pulliam TL","Nay K","Drewry DH","Mukherjee D","Eduful B","Hossain MA","Wells C","Langendorf CG","Oakhill JS","York B","Ramos PZ","Gileadi O","McDonnell DP","Lin C","O'Byrne S","Counago RM","Awad D","Gileadi C","Means AR","Frigo DE"],"additional_accession":[]},"is_claimable":false,"name":"SGC-CAMKK2-1: A Chemical Probe for CAMKK2.","description":"The serine/threonine protein kinase calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) plays critical roles in a range of biological processes. Despite its importance, only a handful of inhibitors of CAMKK2 have been disclosed. Having a selective small molecule tool to interrogate this kinase will help demonstrate that CAMKK2 inhibition can be therapeutically beneficial. Herein, we disclose SGC-CAMKK2-1, a selective chemical probe that targets CAMKK2.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-04T11:33:36.395Z","creation":"2025-04-04T11:33:36.395Z"},"accession":"S-EPMC9856672","cross_references":{"pubmed":["36672221"],"doi":["10.3390/cells12020287"]}}