biostudies-literatureWells CSão Paulo Research FoundationNational Council for Scientific and Technological DevelopmentWellcome TrustGenome CanadaNIH HHS287https://www.ebi.ac.uk/biostudies/studies/S-EPMC9856672biostudies-literatureUnknown12(2)The serine/threonine protein kinase calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) plays critical roles in a range of biological processes. Despite its importance, only a handful of inhibitors of CAMKK2 have been disclosed. Having a selective small molecule tool to interrogate this kinase will help demonstrate that CAMKK2 inhibition can be therapeutically beneficial. Herein, we disclose SGC-CAMKK2-1, a selective chemical probe that targets CAMKK2.CellsSGC-CAMKK2-1: A Chemical Probe for CAMKK2.PMC98566722014/50897-0465651/2014-3106169/ZZ14/Z1061691U24DK116204-01R01CA2184422013/50724-5115766NIH R01CA184208Stork BScott JWCatta-Preta CMCRacioppi LLiang YPulliam TLNay KDrewry DHMukherjee DEduful BHossain MAWells CLangendorf CGOakhill JSYork BRamos PZGileadi OMcDonnell DPLin CO'Byrne SCounago RMAwad DGileadi CMeans ARFrigo DEfalseSGC-CAMKK2-1: A Chemical Probe for CAMKK2.The serine/threonine protein kinase calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) plays critical roles in a range of biological processes. Despite its importance, only a handful of inhibitors of CAMKK2 have been disclosed. Having a selective small molecule tool to interrogate this kinase will help demonstrate that CAMKK2 inhibition can be therapeutically beneficial. Herein, we disclose SGC-CAMKK2-1, a selective chemical probe that targets CAMKK2.2023-01-01T00:00:00Z2023 Jan2025-04-04T11:33:36.395Z2025-04-04T11:33:36.395ZS-EPMC98566723667222110.3390/cells12020287