{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Celen I"],"funding":["NIH NIGMS IDeA Program","Sigma Xi","NASA","Delaware INBRE","Delaware EPSCoR","NIGMS NIH HHS"],"pagination":["270"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9856674"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(2)"],"pubmed_abstract":["Given the growing interest in human exploration of space, it is crucial to identify the effects of space conditions on biological processes. Here, we analyze the transcriptomic response of <i>Caenorhabditis elegans</i> to simulated microgravity and observe the maintained transcriptomic response after returning to ground conditions for four, eight, and twelve days. We show that 75% of the simulated microgravity-induced changes on gene expression persist after returning to ground conditions for four days while most of these changes are reverted after twelve days. Our results from integrative RNA-seq and mass spectrometry analyses suggest that simulated microgravity affects longevity-regulating insulin/IGF-1 and sphingolipid signaling pathways. Finally, we identified 118 genes that are commonly differentially expressed in simulated microgravity- and space-exposed worms. Overall, this work provides insight into the effect of microgravity on biological systems during and after exposure."],"journal":["Cells"],"pubmed_title":["Transcriptomic Signature of the Simulated Microgravity Response in <i>Caenorhabditis elegans</i> and Comparison to Spaceflight Experiments."],"pmcid":["PMC9856674"],"funding_grant_id":["G2016100191301836,","NSF EPS-0814251","NIH/NIGMS GM103446","P20 GM103446","NNX10AN63H","#P20 GM103446","NNX12AR59G","NNX13AM08G","NSF IIA-1330446"],"pubmed_authors":["Celen I","Jayasinghe A","Doh JH","Sabanayagam CR"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptomic Signature of the Simulated Microgravity Response in <i>Caenorhabditis elegans</i> and Comparison to Spaceflight Experiments.","description":"Given the growing interest in human exploration of space, it is crucial to identify the effects of space conditions on biological processes. Here, we analyze the transcriptomic response of <i>Caenorhabditis elegans</i> to simulated microgravity and observe the maintained transcriptomic response after returning to ground conditions for four, eight, and twelve days. We show that 75% of the simulated microgravity-induced changes on gene expression persist after returning to ground conditions for four days while most of these changes are reverted after twelve days. Our results from integrative RNA-seq and mass spectrometry analyses suggest that simulated microgravity affects longevity-regulating insulin/IGF-1 and sphingolipid signaling pathways. Finally, we identified 118 genes that are commonly differentially expressed in simulated microgravity- and space-exposed worms. Overall, this work provides insight into the effect of microgravity on biological systems during and after exposure.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2026-04-08T11:24:35.028Z","creation":"2025-02-19T04:45:51.287Z"},"accession":"S-EPMC9856674","cross_references":{"pubmed":["36672205"],"doi":["10.3390/cells12020270"]}}