biostudies-literatureZhuang YNatural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of China474https://www.ebi.ac.uk/biostudies/studies/S-EPMC9856814biostudies-literatureUnknown15(2)Early metastasis and resistance to traditional therapy are responsible for the poor prognosis of pancreatic adenocarcinoma patients. Metal-dependent protein phosphatases (PPMs) have been proven to play a crucial role in the initiation and progression of various tumors. Nevertheless, the expression and function of distinct PPMs in pancreatic adenocarcinoma have not been fully elucidated. In this study, we investigated the mRNA expression level, prognostic value, and the relationship between the expression of PPMs and the tumor microenvironment in pancreatic adenocarcinoma using Oncomine, TCGA and GTEx, GEO, Kaplan-Meier plotter, STRING, GeneMANIA, and HPA databases and R packages. GO and KEGG analysis revealed that PPMs and their differential co-expression genes are attributed to cell-cell CancersComprehensive Analysis of PPMs in Pancreatic Adenocarcinoma Indicates the Value of <i>PPM1K</i> in the Tumor Microenvironment.PMC98568142021A151501027082073150Lan SHuang FZhong WZhang SPeng JZhuang YfalseComprehensive Analysis of PPMs in Pancreatic Adenocarcinoma Indicates the Value of <i>PPM1K</i> in the Tumor Microenvironment.Early metastasis and resistance to traditional therapy are responsible for the poor prognosis of pancreatic adenocarcinoma patients. Metal-dependent protein phosphatases (PPMs) have been proven to play a crucial role in the initiation and progression of various tumors. Nevertheless, the expression and function of distinct PPMs in pancreatic adenocarcinoma have not been fully elucidated. In this study, we investigated the mRNA expression level, prognostic value, and the relationship between the expression of PPMs and the tumor microenvironment in pancreatic adenocarcinoma using Oncomine, TCGA and GTEx, GEO, Kaplan-Meier plotter, STRING, GeneMANIA, and HPA databases and R packages. GO and KEGG analysis revealed that PPMs and their differential co-expression genes are attributed to cell-cell 2023-01-01T00:00:00Z2023 Jan2025-04-22T09:07:45.212Z2024-11-21T01:04:28.805ZS-EPMC98568143667242310.3390/cancers15020474