biostudies-literatureKimbrel NANIMH NIH HHS135-145https://www.ebi.ac.uk/biostudies/studies/S-EPMC9857322biostudies-literatureUnknown80(2)<h4>Importance</h4>Suicide is a leading cause of death; however, the molecular genetic basis of suicidal thoughts and behaviors (SITB) remains unknown.<h4>Objective</h4>To identify novel, replicable genomic risk loci for SITB.<h4>Design, setting, and participants</h4>This genome-wide association study included 633 778 US military veterans with and without SITB, as identified through electronic health records. GWAS was performed separately by ancestry, controlling for sex, age, and genetic substructure. Cross-ancestry risk loci were identified through meta-analysis. Study enrollment began in 2011 and is ongoing. Data were analyzed from November 2021 to August 2022.<h4>Main outcome and measures</h4>SITB.<h4>Results</h4>A total of 633 778 US military veterans were included in the analysis (57JAMA psychiatryIdentification of Novel, Replicable Genetic Risk Loci for Suicidal Thoughts and Behaviors Among US Military Veterans.PMC9857322R01 MH123489Iruvanti PThornton LMMartin NGRamsey CMOtsuka IRozanov VFernandez-Aranda FMarx CEGappy SJhala DSchaefferkoetter NJamain SCrawford SGutierrez SHauser MACohn JDHair LPJain SEsko TDemontis DBrewer JVOkusaga OSmith DJLane MJQin XJXu JMartindale SLChurby LCuellar-Hengartner LDo NMartins SBSantel DGibson GGaddy MHuq MShabalin AUrsano RJRatcliffe NWitt SHStein MBHuffman JERobey BMiller IWhooley MWhiteman DCHarley JLiangpunsakul SNurnberger JIDocherty ARCampos AICheung KHYilmaz ZGallinger SRoss GFullerton JMMathew RZhao HMyers RMGupta SJimenez-Murcia SKlein JDennis MFSwinkels CChoudhury SManore CCoon HAwasthi SOlsen CHengartner NWRoepke SShura RDBrandt HStrober MCliff AMTownsend AEdwards ACZamora-Resendiz RAgarwal KFinley PDNordentoft MAndreassen OAWells JMedland SEHurley RAErlangsen AVillareal GStarnawska ATsao PSAslan MLi DLagergren JHKaplan ADNaylor JCMeyer LTupler LAYoon HJWallbom AMeyer PKainer DHakonarson HMcDonald SDAgerbo ELori AGanguly KKaplan ASHougaard DMLiu CMAshley-Koch AEKilts JDEdenberg HJTrafton JADedert ESullivan KWhittle JHalmi KAMuralidhar SPyarajan SRipke SLiu XDiBlasi EHarvey PDKatz IRSelva LEJohnson CFayad JKranzler HRLindquist JHLevin DRomero JBulik CMKennedy JLRowland JO'Donnell CJPavicic-Venegas MSchmahl CStriker ROkazaki SDeangelis HERauchman MMcArdle RMattocks KFlorez HYoo SMorey RABhushan SGaziano JMMoore SDJacobson DAStahl EAJones PCWilson PWoodside DBLieb KGorwood PMillion Veteran Program Suicide Exemplar Workgroup, the International Suicide Genetics Consortium, the Veterans Affairs Mid-Atlantic Mental Illness Research, Education, and Clinical Center Workgroup, and the Veterans Affairs Million Veteran ProgramGuo YKo JCPestian JWhitbourne SBKimbrel NAShi YLiao SCChen HCChang KMArgyres DPRajeevan NWangia-Anderson VKinlay SMorrow DHauser ERWendt FGodschalk MMoser JGarrett MEHumphries DEDellitalia LPorteous DRamoz NBeckham JCHauser EAhuja SRuderfer DMCrivelli SWare EBChen WJSu MHShayan SABallas ZMoorman JLevey DFKolade BMors OZillich LFairbank JALichy JLilenfeld LKuo PHKim MMarshall CRHammer KStapley TKessler RCKeel PKMonson ETVan Voorhees EEConner TLewis CMTandon NChristensen EDHishimoto ABakian ASherman SServatius RMcDevitt-Cashman MMcMahon BHRenteria MEMann JJSriram PChang XCalhoun PSGreco JAdams MRamoni RMurdoch MTamang SRHafferty JDMitchell JEGalfalvy HDhaubhadel SKaye WHSokolowski MColeman JRIHuang GWillour VStephens BKaminsky LBrown BSun NGelernter JBoyko EPistis GStreit FBegoli EKlump KLWasserman DWang XIvins DKang JMcCarthy JFConstans JMadduri RKHwu HGBreen GOslin DWGelernter JEMastorides SGarvin MRCasas JPBrophy MTSun YTreasure JMullins NBergen AWKember RLPinto DMagistretti PJJacono FYang RHurley RRibeiro RDuriez PHung APowers AGlatt SJRodriguez AMurnyak BScherer SWBorglum ADBohus MCho KWalker AMcIntosh AMWerge TLi QSYeh SSGandal MHamner MKirby ACBerrettini WHYoash-Gantz RCrow SBhattacharya TWatson HJBreeling JStrollo POursler KAElbogen EBMorgan TFichter MMfalseIdentification of Novel, Replicable Genetic Risk Loci for Suicidal Thoughts and Behaviors Among US Military Veterans.<h4>Importance</h4>Suicide is a leading cause of death; however, the molecular genetic basis of suicidal thoughts and behaviors (SITB) remains unknown.<h4>Objective</h4>To identify novel, replicable genomic risk loci for SITB.<h4>Design, setting, and participants</h4>This genome-wide association study included 633 778 US military veterans with and without SITB, as identified through electronic health records. GWAS was performed separately by ancestry, controlling for sex, age, and genetic substructure. Cross-ancestry risk loci were identified through meta-analysis. Study enrollment began in 2011 and is ongoing. Data were analyzed from November 2021 to August 2022.<h4>Main outcome and measures</h4>SITB.<h4>Results</h4>A total of 633 778 US military veterans were included in the analysis (572023-01-01T00:00:00Z2023 Feb2026-05-28T13:02:58.655Z2025-04-04T21:20:29.007ZS-EPMC98573223651592510.1001/jamapsychiatry.2022.3896