biostudies-literatureUnknown12(2)Liu XPropolis is resinous natural product produced by Western honeybees using beeswax and plant and bud exudates, which has a wide range of biological activities, including antioxidation, antibacterial, anti-inflammation, immune regulation, antitumor, and so on. Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer, and accounts for about 30% of all lymphomas. The effect of poplar propolis on DLBCL has not been reported. The IC₅₀ of propolis on the proliferation of DLBCL SU-DHL-2 cell line and its proteins and gene expressions were detected by CCK-8 kit, label-free proteomic, and RT-PCR. The results showed that the IC₅₀ of propolis at the 5 × l05/mL cell for 24 h was 5.729 μg/mL. Label-free-based proteomics analysis showed that there were 115 differentially expressFoods (Basel, Switzerland)283https://www.ebi.ac.uk/biostudies/studies/S-EPMC9857396biostudies-literatureAntitumor Effects of Poplar Propolis on DLBCL SU-DHL-2 Cells.PMC9857396Liu XYang WTian YMiao XYang AZhang CfalseAntitumor Effects of Poplar Propolis on DLBCL SU-DHL-2 Cells.Propolis is resinous natural product produced by Western honeybees using beeswax and plant and bud exudates, which has a wide range of biological activities, including antioxidation, antibacterial, anti-inflammation, immune regulation, antitumor, and so on. Diffuse large B-cell lymphoma (DLBCL) is an aggressive cancer, and accounts for about 30% of all lymphomas. The effect of poplar propolis on DLBCL has not been reported. The IC₅₀ of propolis on the proliferation of DLBCL SU-DHL-2 cell line and its proteins and gene expressions were detected by CCK-8 kit, label-free proteomic, and RT-PCR. The results showed that the IC₅₀ of propolis at the 5 × l05/mL cell for 24 h was 5.729 μg/mL. Label-free-based proteomics analysis showed that there were 115 differentially express2023-01-01T00:00:00Z2023 Jan2025-04-22T09:07:25.302Z2024-11-21T01:02:48.386ZS-EPMC98573963667337510.3390/foods12020283