{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["80(3)"],"submitter":["Meinel TR"],"pubmed_abstract":["<h4>Importance</h4>International guidelines recommend avoiding intravenous thrombolysis (IVT) in patients with ischemic stroke who have a recent intake of a direct oral anticoagulant (DOAC).<h4>Objective</h4>To determine the risk of symptomatic intracranial hemorrhage (sICH) associated with use of IVT in patients with recent DOAC ingestion.<h4>Design, setting, and participants</h4>This international, multicenter, retrospective cohort study included 64 primary and comprehensive stroke centers across Europe, Asia, Australia, and New Zealand. Consecutive adult patients with ischemic stroke who received IVT (both with and without thrombectomy) were included. Patients whose last known DOAC ingestion was more than 48 hours before stroke onset were excluded. A total of 832 patients with recent DO"],"journal":["JAMA neurology"],"pagination":["233-243"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9857462"],"repository":["biostudies-literature"],"pubmed_title":["Intravenous Thrombolysis in Patients With Ischemic Stroke and Recent Ingestion of Direct Oral Anticoagulants."],"pmcid":["PMC9857462"],"pubmed_authors":["Hong KS","Kowarik M","Beharry J","Honig A","Kim WJ","Nederkoorn PJ","Wegener S","Wu TY","Piot I","Ben Hassen W","Kristoffersen ES","Ustrell X","Shin DI","Cereda C","Paolucci M","Cho YJ","Buehrer M","Goganau I","Hahn M","Soo Y","Ziemann U","Migliaccio L","Kallmunzer B","Gensicke H","Ranta A","Ikenberg B","Koga M","Polymeris A","Klammer M","Hong JB","Katan M","Kim DY","Mbroh J","Hong JH","Leker R","Groschel K","Palanikumar L","Psychogios M","Kim DH","Riegler C","Lee SJ","Kim DE","Lee SH","Ramos JN","Giannandrea D","Chew BA","Bejot Y","Kunieda T","Beyeler M","Stefela J","Filioglo A","Mauro M","DeMarchis GM","Davis S","Kwon DH","Sibolt G","Flores A","Park MS","Kellert L","Siepen B","Lee JS","DOAC-IVT Writing Group","Garcia-Esperon C","Zedde M","Oppenheim C","Peters N","Wada S","Litmeier S","Portela PC","Kim BJ","Carmen L","Siedler G","Lun F","Park KY","Purrucker JC","Curtze S","Du H","Marsch A","Werring D","Enz L","Arnold M","Thomalla G","Goeldlin M","Strbian D","Scutelnic A","Lyrer P","Trapasso MC","Suzuki K","Spratt N","Sara B","Tiainen M","Kaesmacher J","Jana Z","Pascarella R","Kermer P","Katharina F","Strambo D","Yaghi S","Mengel A","Ntaios G","Park JM","Marco L","Cho KH","Francesco C","Forlivesi S","Brehm A","Sumaria S","Macha K","Zietz A","Leung T","Dobrocky T","Pezzini A","Simonetti L","Benini M","Fischer U","Piechoviak E","Gentile M","Moratti C","Park HK","Yakushiji Y","Engelter S","Steiner T","Padjen V","Weir L","Mueller M","Mujanovic A","Napoli M","Stretz C","Kang CH","Kim C","Canovas-Verge D","Gwak DS","Diana Isabella D","Lee M","Lee J","Prange U","Kimura K","Han MK","Sohn SI","Simaan N","Bae HJ","Wischmann J","Martinez-Majander N","Jeong HB","Cha JK","Ferri L","Zini A","Fink J","Lee KB","International DOAC-IVT, TRISP, and CRCS-K-NIH Collaboration","Schlemm E","Naggara O","Erdur H","Wilson D","Jang SH","Roten L","Simon H","von Rennenberg R","Grisendi I","Salerno A","Kleinig TJ","Cordonnier C","Barbu G","Kagi G","Jung S","Lee KJ","Meinel TR","Ip B","Gomez-Exposito A","Kim JY","Marto JP","Kurmann C","Tunnerhoff J","Lee BC","Wang Y","Kang J","Kang K","Park H","Oh MS","Marti-Fabregas J","Scheitz JF","Barber PA","Kim JT","Gassmann L","Ringleb P","Ronning OM","Yum KS","Altersberger V","Wiest R","Michel P","Park TH","Kim JG","Bigliardi G","Tan P","Pesavento L","Kwon JH","Thilemann S","Turc G","Uphaus T","Park SS","Ercegovac M","Yassi N","Poli K","Yu KH","Veltkamp R","Poli S","Choi PMC","Haupenthal D","Kim YS","Choi JC","Nolte CH","Romoli M","Hakim A","Traenka C","Benzakoun J","Berisavac I","Campbell B","Choi KH","Bucke P","Sero L","Seiffge DJ"],"additional_accession":[]},"is_claimable":false,"name":"Intravenous Thrombolysis in Patients With Ischemic Stroke and Recent Ingestion of Direct Oral Anticoagulants.","description":"<h4>Importance</h4>International guidelines recommend avoiding intravenous thrombolysis (IVT) in patients with ischemic stroke who have a recent intake of a direct oral anticoagulant (DOAC).<h4>Objective</h4>To determine the risk of symptomatic intracranial hemorrhage (sICH) associated with use of IVT in patients with recent DOAC ingestion.<h4>Design, setting, and participants</h4>This international, multicenter, retrospective cohort study included 64 primary and comprehensive stroke centers across Europe, Asia, Australia, and New Zealand. Consecutive adult patients with ischemic stroke who received IVT (both with and without thrombectomy) were included. Patients whose last known DOAC ingestion was more than 48 hours before stroke onset were excluded. A total of 832 patients with recent DO","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2026-06-14T06:53:30.599Z","creation":"2025-04-19T10:00:48.273Z"},"accession":"S-EPMC9857462","cross_references":{"pubmed":["36807495"],"doi":["10.1001/jamaneurol.2022.4782"]}}