{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu M"],"funding":["National Key R&D Program of China","Natural Science Foundation of Zhejiang Province","Research Fund from Wenzhou Medical University","Scientific Research Fund of Zhejiang Provincial Education Department","National Natural Science Foundation of China","Fundamental Research Project of Wenzhou Bureau of Science and Technology"],"pagination":["24"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9857501"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(1)"],"pubmed_abstract":["Oxidative stress is considered as a major factor causing retinal pigment epithelium (RPE) dysfunction and finally leading to retinal diseases such as age-related macular degeneration (AMD). Developing hydrogels for RPE cell delivery, especially those with antioxidant feature, is emerging as a promising approach for AMD treatment. Herein, a readily prepared antioxidant alginate-based hydrogel was developed to serve as a cytoprotective agent for RPE cells against oxidative damage. Alg-BOB was synthesized via conjugation of benzoxaborole (BOB) to the polysaccharide backbone. Hydrogels were formed through self-crosslinking of Alg-BOB based on benzoxaborole-diol complexation. The resulting hydrogel showed porous micro-structure, pH dependent mechanical strength and excellent self-healing, remol"],"journal":["Gels (Basel, Switzerland)"],"pubmed_title":["Self-Healing Alginate Hydrogel Formed by Dynamic Benzoxaborolate Chemistry Protects Retinal Pigment Epithelium Cells against Oxidative Damage."],"pmcid":["PMC9857501"],"funding_grant_id":["52003199","KYYW201916","Y20180230","KYQD20190515","2016YFC1101201","Y202147886","LQ20E030010"],"pubmed_authors":["Yang W","Narain R","Huang Y","Pan T","Liu M","Chen J","Zhu L","Tao C","Chen Y","Nan K"],"additional_accession":[]},"is_claimable":false,"name":"Self-Healing Alginate Hydrogel Formed by Dynamic Benzoxaborolate Chemistry Protects Retinal Pigment Epithelium Cells against Oxidative Damage.","description":"Oxidative stress is considered as a major factor causing retinal pigment epithelium (RPE) dysfunction and finally leading to retinal diseases such as age-related macular degeneration (AMD). Developing hydrogels for RPE cell delivery, especially those with antioxidant feature, is emerging as a promising approach for AMD treatment. Herein, a readily prepared antioxidant alginate-based hydrogel was developed to serve as a cytoprotective agent for RPE cells against oxidative damage. Alg-BOB was synthesized via conjugation of benzoxaborole (BOB) to the polysaccharide backbone. Hydrogels were formed through self-crosslinking of Alg-BOB based on benzoxaborole-diol complexation. The resulting hydrogel showed porous micro-structure, pH dependent mechanical strength and excellent self-healing, remol","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-26T00:36:36.702Z","creation":"2025-04-06T09:47:58.534Z"},"accession":"S-EPMC9857501","cross_references":{"pubmed":["36661792"],"doi":["10.3390/gels9010024"]}}