biostudies-literatureElias MDNHLBI NIH HHSNIGMS NIH HHSe2248987https://www.ebi.ac.uk/biostudies/studies/S-EPMC9857632biostudies-literatureUnknown6(1)<h4>Importance</h4>Data are limited regarding adverse reactions after COVID-19 vaccination in patients with a history of multisystem inflammatory syndrome in children (MIS-C). The lack of vaccine safety data in this unique population may cause hesitancy and concern for many families and health care professionals.<h4>Objective</h4>To describe adverse reactions following COVID-19 vaccination in patients with a history of MIS-C.<h4>Design, setting, and participants</h4>In this multicenter cross-sectional study including 22 North American centers participating in a National Heart, Lung, and Blood Institute, National Institutes of Health-sponsored study, Long-Term Outcomes After the Multisystem Inflammatory Syndrome in Children (MUSIC), patients with a prior diagnosis of MIS-C who were eligibleJAMA network openExamination of Adverse Reactions After COVID-19 Vaccination Among Patients With a History of Multisystem Inflammatory Syndrome in Children.PMC9857632UG1 HL135646U54 GM115428Artis CMitscher GTruong DTSabati AWilliams HHonig JFagatele LWilliams ECarr MAtkins DTaylor MShakti DHunsberger SALipkin PTaylor CPatel JOsakwe OHannah BMu XHite MDragulescu AWong PCBroberg CKnight TJKatz DPorche JRussell MHu CLeek TSRathge KSanil YSerrano FMorgan LMMorrison TRojas WMcCrindle BWMbiydzenyuy DHandler SSMooney ARolland MMiller JShea RAmsellem RRubio KGiglia TMSchott CEgerson DBickford MKazlova VGallagher CWilliams-Farr CJohnson LMWeiland MDMartyrosyan KTrachtenberg FLMoussi EAmarnath AKertis JAPearson GLitt SCrane KVemula PStack SEyob LElias MDBowman DDavis MBurns KMParker PUndyala VKajimoto HHobbs CVHerzberg AHebson CBirmingham EGamulka BTyler SDriscoll DJNelson JEvans BHowell JBlock JHarahsheh AThacker DGlassmeyer ISharma KSylvester DEvans FSullivan CSykes MForsha DDionne AJones JMartinez MJohnson MSullivan NHayes KBarton NSpaeder MMahony LLanzilotta KMitchell ECStumpf MSeibert EJohnson AHaverty MOrav GGoodell LRRudow MLupton KJone PNKinhikar CMarks GAmbrosoli JLiu AAnderson BGobburu JYeung RPena SLemus Rangel MPediatric Heart Network MUSIC Study InvestigatorsZhang MMuniz JCSaul JPJoyce MBeckley MAD'Addese LFrosch OHMcGeoghegan PHasbani KRowe RHock KAlbizem DPignatelli RMorato JGSShaffer KVotava-Smith JKMacias IMaldonado JPemberton VWalter PBradford TTPortman MAJohnston MKrishnan AGaruba OShekerdemian LHunsberger SSagiv ESzmuszkovicz JRAggarwal SDugan LPowell AMohandas SParnell ASNair DGGermann JSu JAFerreira RCole RSexson Tejtel SKNero RGordy DDowney RWorrell AEChang MDiStefano LAlmaguer MOster MEHoward CMGentry SShamailova OAlaby DSanchez CMahanta SBowie TClarke ACheng ALSavadkar SLambert LMarcus EWatson LConnors TJZadokar VBurnett MBaker ASingh GSperotto FPomeroy LMcQuillen PWang SSlayton BMcHugh KEOwada CCrosby-Thompson ALe KMackie APark SVan't Hof KLang SMNowlen TKochilas LStrelow JWhite ZFriedman KChrisant MMahle WTMcCall MProspero CLam CAlmasnaah ABainton JPancheri JBuckley LJMohazabnia PBerul CSanders-Lewis KBarr MRDummer KBOlivieri LFetch ACastleberry CCampbell MJPayne RMSrivastava SSmith PGiorgio TCurless AMarshall AKhan NDoman TNewburger JWfalseExamination of Adverse Reactions After COVID-19 Vaccination Among Patients With a History of Multisystem Inflammatory Syndrome in Children.<h4>Importance</h4>Data are limited regarding adverse reactions after COVID-19 vaccination in patients with a history of multisystem inflammatory syndrome in children (MIS-C). The lack of vaccine safety data in this unique population may cause hesitancy and concern for many families and health care professionals.<h4>Objective</h4>To describe adverse reactions following COVID-19 vaccination in patients with a history of MIS-C.<h4>Design, setting, and participants</h4>In this multicenter cross-sectional study including 22 North American centers participating in a National Heart, Lung, and Blood Institute, National Institutes of Health-sponsored study, Long-Term Outcomes After the Multisystem Inflammatory Syndrome in Children (MUSIC), patients with a prior diagnosis of MIS-C who were eligible2023-01-01T00:00:00Z2023 Jan2026-07-09T12:23:09.289Z2025-04-06T19:16:13.302ZS-EPMC98576323659529610.1001/jamanetworkopen.2022.48987