biostudies-literatureChristenson ESNCATS NIH HHSRaymond and Melody Ranelli FundCharles T. Bauer FoundationNCI NIH HHSSwim Across AmericaCancer Convergence InstituteBloomberg-Kimmel Institute for Cancer Immunotherapy75-84https://www.ebi.ac.uk/biostudies/studies/S-EPMC9858144biostudies-literatureUnknown30(1)Solid organ transplants are associated with a modestly increased risk of colorectal cancers (CRC). However, the molecular profile of these cancers has not been described. We hypothesized that transplant-related immunosuppression may promote development of more immunogenic tumors as suggested by a high tumor mutation burden or mismatch repair deficiency. We performed an electronic medical record search for patients seen in the Johns Hopkins University Health System (JHHS) between 2017 and 2022 who developed CRC following solid organ transplantation. A comparator cohort of patients treated for CRC at JHHS with molecular profiling data was also identified. In this case, 29 patients were identified that developed post-transplant CRC (renal transplant, <i>n</i> = 18; liver transplant, <i>n</i> Current oncology (Toronto, Ont.)Solid Organ Transplantation Is Associated with an Increased Rate of Mismatch Repair Deficiency and PIK3CA Mutations in Colorectal Cancer.PMC9858144UL1 TR003098P50 CA062924Jaffee EMDe Jesus-Acosta AGurakar AAzad NBrennan DCBever KLe DTWang HLee VLin MTChristenson ESYarchoan MfalseSolid Organ Transplantation Is Associated with an Increased Rate of Mismatch Repair Deficiency and PIK3CA Mutations in Colorectal Cancer.Solid organ transplants are associated with a modestly increased risk of colorectal cancers (CRC). However, the molecular profile of these cancers has not been described. We hypothesized that transplant-related immunosuppression may promote development of more immunogenic tumors as suggested by a high tumor mutation burden or mismatch repair deficiency. We performed an electronic medical record search for patients seen in the Johns Hopkins University Health System (JHHS) between 2017 and 2022 who developed CRC following solid organ transplantation. A comparator cohort of patients treated for CRC at JHHS with molecular profiling data was also identified. In this case, 29 patients were identified that developed post-transplant CRC (renal transplant, <i>n</i> = 18; liver transplant, <i>n</i> 2022-01-01T00:00:00Z2022 Dec2025-08-23T03:04:50.882Z2025-04-06T09:48:05.681ZS-EPMC98581443666165510.3390/curroncol30010006