{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Haghverdi L"],"funding":["NHGRI NIH HHS"],"pagination":["13-25"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9860164"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(1)"],"pubmed_abstract":["The concept of cell fate relates to the future identity of a cell, and its daughters, which is obtained via cell differentiation and division. Understanding, predicting, and manipulating cell fate has been a long-sought goal of developmental and regenerative biology. Recent insights obtained from single-cell genomic and integrative lineage-tracing approaches have further aided to identify molecular features predictive of cell fate. In this perspective, we discuss these approaches with a focus on theoretical concepts and future directions of the field to dissect molecular mechanisms underlying cell fate."],"journal":["Stem cell reports"],"pubmed_title":["Single-cell multi-omics and lineage tracing to dissect cell fate decision-making."],"pmcid":["PMC9860164"],"funding_grant_id":["UM1 HG012076"],"pubmed_authors":["Ludwig LS","Haghverdi L"],"additional_accession":[]},"is_claimable":false,"name":"Single-cell multi-omics and lineage tracing to dissect cell fate decision-making.","description":"The concept of cell fate relates to the future identity of a cell, and its daughters, which is obtained via cell differentiation and division. Understanding, predicting, and manipulating cell fate has been a long-sought goal of developmental and regenerative biology. Recent insights obtained from single-cell genomic and integrative lineage-tracing approaches have further aided to identify molecular features predictive of cell fate. In this perspective, we discuss these approaches with a focus on theoretical concepts and future directions of the field to dissect molecular mechanisms underlying cell fate.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2026-06-03T18:29:25.909Z","creation":"2025-04-05T18:36:20.181Z"},"accession":"S-EPMC9860164","cross_references":{"pubmed":["36630900"],"doi":["10.1016/j.stemcr.2022.12.003"]}}