{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tai CJ"],"funding":["Ministry of Science and Technology","National Science and Technology Council","National Sun Yat-sen University-Kaohsiung Medical University Joint Research Projects"],"pagination":["1252"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9860656"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(2)"],"pubmed_abstract":["Continuing chemical investigation of the Red Sea sponge <i>Spongia</i> sp. led to the isolation of four new 3,4-<i>seco</i>-3,19-dinorspongian diterpenoid lactones, secodinorspongins A-D (<b>1</b>-<b>4</b>), along with a classical spongian diterpenoid lactone, sponginolide (<b>5</b>). The chemical structures, including the absolute configurations of these compounds, were elucidated using the extensive spectroscopic study composed of 1D and 2D NMR data analyses, and a comparison between calculated-electronic-circular-dichroism (ECD) and experimental-circular-dichroism (CD) spectra. A plausible biosynthetic pathway of <b>1</b>-<b>4</b> was also proposed. Furthermore, the cytotoxicity, antibacterial and anti-inflammatory activities of <b>1</b>-<b>5</b> were evaluated. Compound <b>1</b> was found to exhibit inhibitory activity against the growth of <i>Staphylococcus aureus</i> (<i>S. aureus</i>), and <b>4</b> and <b>5</b> exhibited suppression of superoxide-anion generation and elastase release in fMLF/CB-induced human neutrophils."],"journal":["International journal of molecular sciences"],"pubmed_title":["New 3,4-<i>seco</i>-3,19-Dinor- and Spongian-Based Diterpenoid Lactones from the Marine Sponge <i>Spongia</i> sp."],"pmcid":["PMC9860656"],"funding_grant_id":["110-P016","111-2320-B-110-010","109-2320-B-291-001-MY3","NSYSUKMU 109-I002","MOST 108-2320-B-110-003-MY2","110-2320-B-110-001","111-2811-B-291-002"],"pubmed_authors":["Hwang TL","Chao CH","Ahmed AF","Yen CH","Tai CJ","Huang YM","Sheu JH","Chang FR"],"additional_accession":[]},"is_claimable":false,"name":"New 3,4-<i>seco</i>-3,19-Dinor- and Spongian-Based Diterpenoid Lactones from the Marine Sponge <i>Spongia</i> sp.","description":"Continuing chemical investigation of the Red Sea sponge <i>Spongia</i> sp. led to the isolation of four new 3,4-<i>seco</i>-3,19-dinorspongian diterpenoid lactones, secodinorspongins A-D (<b>1</b>-<b>4</b>), along with a classical spongian diterpenoid lactone, sponginolide (<b>5</b>). The chemical structures, including the absolute configurations of these compounds, were elucidated using the extensive spectroscopic study composed of 1D and 2D NMR data analyses, and a comparison between calculated-electronic-circular-dichroism (ECD) and experimental-circular-dichroism (CD) spectra. A plausible biosynthetic pathway of <b>1</b>-<b>4</b> was also proposed. Furthermore, the cytotoxicity, antibacterial and anti-inflammatory activities of <b>1</b>-<b>5</b> were evaluated. Compound <b>1</b> was found to exhibit inhibitory activity against the growth of <i>Staphylococcus aureus</i> (<i>S. aureus</i>), and <b>4</b> and <b>5</b> exhibited suppression of superoxide-anion generation and elastase release in fMLF/CB-induced human neutrophils.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-04T11:33:08.329Z","creation":"2025-04-04T11:33:08.329Z"},"accession":"S-EPMC9860656","cross_references":{"pubmed":["36674768"],"doi":["10.3390/ijms24021252"]}}