biostudies-literatureTai CJMinistry of Science and TechnologyNational Science and Technology CouncilNational Sun Yat-sen University-Kaohsiung Medical University Joint Research Projects1252https://www.ebi.ac.uk/biostudies/studies/S-EPMC9860656biostudies-literatureUnknown24(2)Continuing chemical investigation of the Red Sea sponge <i>Spongia</i> sp. led to the isolation of four new 3,4-<i>seco</i>-3,19-dinorspongian diterpenoid lactones, secodinorspongins A-D (<b>1</b>-<b>4</b>), along with a classical spongian diterpenoid lactone, sponginolide (<b>5</b>). The chemical structures, including the absolute configurations of these compounds, were elucidated using the extensive spectroscopic study composed of 1D and 2D NMR data analyses, and a comparison between calculated-electronic-circular-dichroism (ECD) and experimental-circular-dichroism (CD) spectra. A plausible biosynthetic pathway of <b>1</b>-<b>4</b> was also proposed. Furthermore, the cytotoxicity, antibacterial and anti-inflammatory activities of <b>1</b>-<b>5</b> were evaluated. Compound <b>1</b> was found to exhibit inhibitory activity against the growth of <i>Staphylococcus aureus</i> (<i>S. aureus</i>), and <b>4</b> and <b>5</b> exhibited suppression of superoxide-anion generation and elastase release in fMLF/CB-induced human neutrophils.International journal of molecular sciencesNew 3,4-<i>seco</i>-3,19-Dinor- and Spongian-Based Diterpenoid Lactones from the Marine Sponge <i>Spongia</i> sp.PMC9860656110-P016111-2320-B-110-010109-2320-B-291-001-MY3NSYSUKMU 109-I002MOST 108-2320-B-110-003-MY2110-2320-B-110-001111-2811-B-291-002Hwang TLChao CHAhmed AFYen CHTai CJHuang YMSheu JHChang FRfalseNew 3,4-<i>seco</i>-3,19-Dinor- and Spongian-Based Diterpenoid Lactones from the Marine Sponge <i>Spongia</i> sp.Continuing chemical investigation of the Red Sea sponge <i>Spongia</i> sp. led to the isolation of four new 3,4-<i>seco</i>-3,19-dinorspongian diterpenoid lactones, secodinorspongins A-D (<b>1</b>-<b>4</b>), along with a classical spongian diterpenoid lactone, sponginolide (<b>5</b>). The chemical structures, including the absolute configurations of these compounds, were elucidated using the extensive spectroscopic study composed of 1D and 2D NMR data analyses, and a comparison between calculated-electronic-circular-dichroism (ECD) and experimental-circular-dichroism (CD) spectra. A plausible biosynthetic pathway of <b>1</b>-<b>4</b> was also proposed. Furthermore, the cytotoxicity, antibacterial and anti-inflammatory activities of <b>1</b>-<b>5</b> were evaluated. Compound <b>1</b> was found to exhibit inhibitory activity against the growth of <i>Staphylococcus aureus</i> (<i>S. aureus</i>), and <b>4</b> and <b>5</b> exhibited suppression of superoxide-anion generation and elastase release in fMLF/CB-induced human neutrophils.2023-01-01T00:00:00Z2023 Jan2025-04-04T11:33:08.329Z2025-04-04T11:33:08.329ZS-EPMC98606563667476810.3390/ijms24021252