{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pradal I"],"funding":["Spanish National Research Council","Gobierno del Principado de Asturias"],"pagination":["179"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9860891"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["The rise of antimicrobial resistant (AMR) bacteria is a major health concern, especially with regard to members of the ESKAPE group, to which vancomycin-resistant (VRE) <i>Enterococcus faecium</i> belongs. Phage therapy has emerged as a novel alternative for the treatment of AMR infections. This, however, relies on the isolation and characterisation of a large collection of phages. This work describes the exploration of human faeces as a source of new <i>E. faecium</i>-infecting phages. Phage vB_EfaH_163 was isolated and characterised at the microbiological, genomic, and functional levels. vB_EfaH_163 phage, a new member of <i>Herelleviridae</i>, subfamily <i>Brockvirinae</i>, has a dsDNA genome of 150,836 bp that does not harbour any virulence factors or antibiotic resistance genes. It in"],"journal":["Viruses"],"pubmed_title":["<i>Enterococcus faecium</i> Bacteriophage vB_EfaH_163, a New Member of the <i>Herelleviridae</i> Family, Reduces the Mortality Associated with an <i>E. faecium</i> vanR Clinical Isolate in a <i>Galleria mellonella</i> Animal Model."],"pmcid":["PMC9860891"],"funding_grant_id":["AYUD/2021/50916","CSIC201870I091"],"pubmed_authors":["Pradal I","Del Rio B","Fernandez M","Casado A","Ladero V","Rodriguez-Lucas C","Alvarez MA"],"additional_accession":[]},"is_claimable":false,"name":"<i>Enterococcus faecium</i> Bacteriophage vB_EfaH_163, a New Member of the <i>Herelleviridae</i> Family, Reduces the Mortality Associated with an <i>E. faecium</i> vanR Clinical Isolate in a <i>Galleria mellonella</i> Animal Model.","description":"The rise of antimicrobial resistant (AMR) bacteria is a major health concern, especially with regard to members of the ESKAPE group, to which vancomycin-resistant (VRE) <i>Enterococcus faecium</i> belongs. Phage therapy has emerged as a novel alternative for the treatment of AMR infections. This, however, relies on the isolation and characterisation of a large collection of phages. This work describes the exploration of human faeces as a source of new <i>E. faecium</i>-infecting phages. Phage vB_EfaH_163 was isolated and characterised at the microbiological, genomic, and functional levels. vB_EfaH_163 phage, a new member of <i>Herelleviridae</i>, subfamily <i>Brockvirinae</i>, has a dsDNA genome of 150,836 bp that does not harbour any virulence factors or antibiotic resistance genes. It in","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2026-06-28T03:08:50.357Z","creation":"2024-11-15T19:59:11.095Z"},"accession":"S-EPMC9860891","cross_references":{"pubmed":["36680219"],"doi":["10.3390/v15010179"]}}