biostudies-literatureUnknownAlur-Gupta SUniversity of PennsylvaniaNational Institutes of Health<h4>Objective</h4>To determine whether women with polycystic ovary syndrome (PCOS) had a higher incidence of testing positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) than those without PCOS and evaluate whether PCOS diagnosis independently increased the risk of moderate or severe disease in those with positive SARS-CoV-2 test results.<h4>Design</h4>Retrospective cohort study using the National COVID Cohort Collaborative (N3C).<h4>Setting</h4>National COVID Cohort Collaborative.<h4>Patient(s)</h4>Adult nonpregnant women (age, 18-65 years) enrolled in the N3C with confirmed SARS-CoV-2 testing for any indication. Sensitivity analyses were conducted in women aged 18-49 years and who were obese (body mass index, ≥30 kg/m²).<h4>Intervention(s)</h4>The exposureFertility and sterilityS0015-0282(23)00063-8https://www.ebi.ac.uk/biostudies/studies/S-EPMC9862701biostudies-literatureRisk of severe acute respiratory syndrome coronavirus 2 infection among women with polycystic ovary syndrome.PMC9862701Eichmann DADeacy MGabriel DMichael SGClark MDillon CWu CHong SSPfaff ERDokras AGordon VLee AMLehmann HPZhu RLBramante CBradwell KRBurgoon PWKibbe WACooper WMariona FHarper JRGersing KRStarren JNeumann AJZhang XTZampino ETemple-O'Connor MO'Neil STVolz AMGarbarini NMarti ECGirvin ATGuinney JPalchuk MBSaltz JHSuver CQureshi NLiu HFuentes RSpratt HBoland MRWalters KMFrancis PAManna AAlur-Gupta SVedula SWilliams AEChute CGWalden AKurilla MGBissell MMMisquitta LBozzette SMorris MN3C ConsortiumSaltz MMBennett TDGraves ASaha AHernandez WPortilla LWilcox ABErwin-Cohen RMoffitt RAHaendel MAPayne PRORobinson PNSheikh UMiller RTKoraishy FMKostka KMcMurry JASchmitt CfalseRisk of severe acute respiratory syndrome coronavirus 2 infection among women with polycystic ovary syndrome.<h4>Objective</h4>To determine whether women with polycystic ovary syndrome (PCOS) had a higher incidence of testing positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) than those without PCOS and evaluate whether PCOS diagnosis independently increased the risk of moderate or severe disease in those with positive SARS-CoV-2 test results.<h4>Design</h4>Retrospective cohort study using the National COVID Cohort Collaborative (N3C).<h4>Setting</h4>National COVID Cohort Collaborative.<h4>Patient(s)</h4>Adult nonpregnant women (age, 18-65 years) enrolled in the N3C with confirmed SARS-CoV-2 testing for any indication. Sensitivity analyses were conducted in women aged 18-49 years and who were obese (body mass index, ≥30 kg/m²).<h4>Intervention(s)</h4>The exposure2023-01-01T00:00:00Z2023 Jan2025-04-18T14:52:15.917Z2025-02-18T23:36:56.865ZS-EPMC98627013669355510.1016/j.fertnstert.2023.01.025