{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(1)"],"submitter":["Garcia-Soto S"],"pubmed_abstract":["The cattle-adapted serovar <i>Salmonella</i> Dublin (<i>S</i>. Dublin) causes enteritis and systemic diseases in animals. In the German federal state Schleswig-Holstein, <i>S</i>. Dublin is the most important serovar in cattle indicating an endemic character of the infection. To gain information on dissemination and routes of infection, whole-genome sequencing (WGS) was used to explore the genetic traits of 78 <i>S.</i> Dublin strains collected over a period of six years. The phylogeny was analysed using core-genome single nucleotide polymorphisms (cgSNPs). Genomic clusters at 100, 15 and 1 cgSNPs were selected for molecular analysis. Important specific virulence determinants were detected in all strains but multidrug resistance in <i>S.</i> Dublin organisms was not found. Using 15 cgSNPs epidemiological links between herds were identified, clusters at 1 cgSNPs provided clear evidence on both persistence of <i>S.</i> Dublin at single farms in consecutive years and transmission of the organisms between herds in different distances. A possible risk factor for the repeated occurrence of <i>S.</i> Dublin in certain districts of Schleswig-Holstein might be the spreading of manure on pastures and grassland. Effective control of <i>S.</i> Dublin requires farm-specific analysis of the management supplemented by WGS of outbreak causing <i>S.</i> Dublin strains to clearly identify routes of infection."],"journal":["Microorganisms"],"pagination":["122"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9863307"],"repository":["biostudies-literature"],"pubmed_title":["Epidemiological Analysis on the Occurrence of <i>Salmonella enterica</i> Subspecies <i>enterica</i> Serovar Dublin in the German Federal State Schleswig-Holstein Using Whole-Genome Sequencing."],"pmcid":["PMC9863307"],"pubmed_authors":["Methner U","Garcia-Soto S","Linde J"],"additional_accession":[]},"is_claimable":false,"name":"Epidemiological Analysis on the Occurrence of <i>Salmonella enterica</i> Subspecies <i>enterica</i> Serovar Dublin in the German Federal State Schleswig-Holstein Using Whole-Genome Sequencing.","description":"The cattle-adapted serovar <i>Salmonella</i> Dublin (<i>S</i>. Dublin) causes enteritis and systemic diseases in animals. In the German federal state Schleswig-Holstein, <i>S</i>. Dublin is the most important serovar in cattle indicating an endemic character of the infection. To gain information on dissemination and routes of infection, whole-genome sequencing (WGS) was used to explore the genetic traits of 78 <i>S.</i> Dublin strains collected over a period of six years. The phylogeny was analysed using core-genome single nucleotide polymorphisms (cgSNPs). Genomic clusters at 100, 15 and 1 cgSNPs were selected for molecular analysis. Important specific virulence determinants were detected in all strains but multidrug resistance in <i>S.</i> Dublin organisms was not found. Using 15 cgSNPs epidemiological links between herds were identified, clusters at 1 cgSNPs provided clear evidence on both persistence of <i>S.</i> Dublin at single farms in consecutive years and transmission of the organisms between herds in different distances. A possible risk factor for the repeated occurrence of <i>S.</i> Dublin in certain districts of Schleswig-Holstein might be the spreading of manure on pastures and grassland. Effective control of <i>S.</i> Dublin requires farm-specific analysis of the management supplemented by WGS of outbreak causing <i>S.</i> Dublin strains to clearly identify routes of infection.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2026-04-08T12:11:26.837Z","creation":"2025-02-19T02:24:02.023Z"},"accession":"S-EPMC9863307","cross_references":{"pubmed":["36677417"],"doi":["10.3390/microorganisms11010122"]}}