{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hoene M"],"funding":["German Diabetes Association","University of Tübingen","German Center for Diabetes Research","Sino-German Center for Research Promotion","Open Access Publishing Fund of the University of Tübingen","National Natural Science Foundation of China","Federal Ministry of Education and Research","German Federal Ministry of Education and Research"],"pagination":["15"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9863672"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["Physical exercise is a powerful measure to prevent cardiometabolic diseases. However, the individual response to lifestyle interventions is variable and cannot, to date, be predicted. N-Lactoylphenylalanine (Lac-Phe) produced during exercise has recently been shown to mediate weight loss in obese mice. Lac-Phe could also contribute to, and potentially explain differences in, the effectiveness of exercise interventions in humans. Sedentary overweight and obese subjects completed an 8-week supervised endurance exercise intervention (n = 22). Before and after the intervention, plasma levels of Lac-Phe were determined by UHPLC-MS in the resting state and immediately after an acute bout of endurance exercise. Adipose tissue volume was quantified using MRI. Acute exercise caused a pronounced inc"],"journal":["Metabolites"],"pubmed_title":["Exercise-Induced N-Lactoylphenylalanine Predicts Adipose Tissue Loss during Endurance Training in Overweight and Obese Humans."],"pmcid":["PMC9863672"],"funding_grant_id":["M-0257","01GI0925","21934006","n.a."],"pubmed_authors":["Machann J","Weigert C","Peter A","Niess A","Heni M","Moller A","Xu G","Hoene M","Zhao X","Birkenfeld AL","Lehmann R"],"additional_accession":[]},"is_claimable":false,"name":"Exercise-Induced N-Lactoylphenylalanine Predicts Adipose Tissue Loss during Endurance Training in Overweight and Obese Humans.","description":"Physical exercise is a powerful measure to prevent cardiometabolic diseases. However, the individual response to lifestyle interventions is variable and cannot, to date, be predicted. N-Lactoylphenylalanine (Lac-Phe) produced during exercise has recently been shown to mediate weight loss in obese mice. Lac-Phe could also contribute to, and potentially explain differences in, the effectiveness of exercise interventions in humans. Sedentary overweight and obese subjects completed an 8-week supervised endurance exercise intervention (n = 22). Before and after the intervention, plasma levels of Lac-Phe were determined by UHPLC-MS in the resting state and immediately after an acute bout of endurance exercise. Adipose tissue volume was quantified using MRI. Acute exercise caused a pronounced inc","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-04T10:19:48.15Z","creation":"2025-02-19T00:12:25.399Z"},"accession":"S-EPMC9863672","cross_references":{"pubmed":["36676940"],"doi":["10.3390/metabo13010015"]}}