{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Schumann F"],"funding":["Deutsche Forschungsgemeinschaft and Universität Rostock/Universitätsmedizin Rostock–"],"pagination":["1685"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9865012"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(2)"],"pubmed_abstract":["In Parkinson's disease, hypercholinism in the striatum occurs, with the consequence of disturbed motor functions. Direct application of Botulinum neurotoxin-A in the striatum of hemi-Parkinsonian rats might be a promising anticholinergic therapeutic option. Here, we aimed to determine the spread of intrastriatally injected BoNT-A in the brain as well as the duration of its action based on the distribution of cleaved SNAP-25. Rats were injected with 1 ng of BoNT-A into the right striatum and the brains were examined at different times up to one year after treatment. In brain sections immunohistochemically stained for BoNT-A, cleaved SNAP-25 area-specific densitometric analyses were performed. Increased immunoreactivity for cleaved SNAP-25 was found in brain regions other than the unilateral"],"journal":["International journal of molecular sciences"],"pubmed_title":["Distribution of Cleaved SNAP-25 in the Rat Brain, following Unilateral Injection of Botulinum Neurotoxin-A into the Striatum."],"pmcid":["PMC9865012"],"funding_grant_id":["512855535"],"pubmed_authors":["Hawlitschka A","Schumann F","Wree A","Schmitt O"],"additional_accession":[]},"is_claimable":false,"name":"Distribution of Cleaved SNAP-25 in the Rat Brain, following Unilateral Injection of Botulinum Neurotoxin-A into the Striatum.","description":"In Parkinson's disease, hypercholinism in the striatum occurs, with the consequence of disturbed motor functions. Direct application of Botulinum neurotoxin-A in the striatum of hemi-Parkinsonian rats might be a promising anticholinergic therapeutic option. Here, we aimed to determine the spread of intrastriatally injected BoNT-A in the brain as well as the duration of its action based on the distribution of cleaved SNAP-25. Rats were injected with 1 ng of BoNT-A into the right striatum and the brains were examined at different times up to one year after treatment. In brain sections immunohistochemically stained for BoNT-A, cleaved SNAP-25 area-specific densitometric analyses were performed. Increased immunoreactivity for cleaved SNAP-25 was found in brain regions other than the unilateral","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-08-17T03:08:00.824Z","creation":"2025-05-31T23:31:09.772Z"},"accession":"S-EPMC9865012","cross_references":{"pubmed":["36675200"],"doi":["10.3390/ijms24021685"]}}