{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Khvostov MV"],"funding":["Russian Science Foundation"],"pagination":["44"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9865096"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["Several novel 9-N-n-alkyl derivatives of berberine (C5, C7, C10, C12) were synthesized. They were analyzed in vitro and in vivo for their hypoglycemic activity. In vitro studies showed that the derivatives with shorter alkyl substitutes at concentrations ranging from 2.5 to 10 μM were able to stimulate glucose consumption by HepG2 cells more prominently than the derivatives with longer substitutes (C10 and C12). All compounds demonstrated a better effect compared to berberine. Their impact on cells' viability also depended on the alkyl substitutes length, but in this case, C10 and C12 derivatives demonstrated the best results. A similar correlation was also found in the OGTT, where the C5 derivative demonstrated a pronounced hypoglycemic effect at a dose of 15 mg/kg and C12 was less effect"],"journal":["Pharmaceutics"],"pubmed_title":["9-N-n-alkyl Berberine Derivatives: Hypoglycemic Activity Evaluation."],"pmcid":["PMC9865096"],"funding_grant_id":["20-13-00029"],"pubmed_authors":["Valutsa N","Gladkova ED","Zhukova NA","Tolstikova TG","Borisov SA","Meshkova YV","Marenina MK","Salakhutdinov NF","Luzina OA","Khvostov MV","Fedotova MS"],"additional_accession":[]},"is_claimable":false,"name":"9-N-n-alkyl Berberine Derivatives: Hypoglycemic Activity Evaluation.","description":"Several novel 9-N-n-alkyl derivatives of berberine (C5, C7, C10, C12) were synthesized. They were analyzed in vitro and in vivo for their hypoglycemic activity. In vitro studies showed that the derivatives with shorter alkyl substitutes at concentrations ranging from 2.5 to 10 μM were able to stimulate glucose consumption by HepG2 cells more prominently than the derivatives with longer substitutes (C10 and C12). All compounds demonstrated a better effect compared to berberine. Their impact on cells' viability also depended on the alkyl substitutes length, but in this case, C10 and C12 derivatives demonstrated the best results. A similar correlation was also found in the OGTT, where the C5 derivative demonstrated a pronounced hypoglycemic effect at a dose of 15 mg/kg and C12 was less effect","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-04T14:27:01.454Z","creation":"2025-04-04T14:27:01.454Z"},"accession":"S-EPMC9865096","cross_references":{"pubmed":["36678673"],"doi":["10.3390/pharmaceutics15010044"]}}