biostudies-literatureXu JNational Natural Science Foundation of ChinaTranslational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan UniversityMajor Science and Technology Program of Science, Technology and Innovation Commission of Shenzhen Municipality99https://www.ebi.ac.uk/biostudies/studies/S-EPMC9865294biostudies-literatureUnknown11(1)Leptospirosis is an important zoonosis that is caused by pathogenic Leptospira, which is considered to be a re-emerging infectious disease in many countries. Rodents are the most important reservoirs for both human and animal infection. An epidemiological survey of pathogenic Leptospira in rodents is important for the prevention and control of leptospirosis. In this study, a total of 964 rodents were captured from six cities in Hubei Province, and two pathogenic Leptospira species (L. interrogans and L. borgpetersenii) were detected using nested PCR with an overall prevalence of 4.8%. L. interrogans was distributed in five sampling sites, which may be the dominant species of pathogenic Leptospira in Hubei Province. In addition, Rattus norvegicus showed a relatively high infection rate, whiMicroorganismsPathogenic <i>Leptospira</i> Infections in Hubei Province, Central China.PMC9865294ZNLH20220381991220308U20A20396JCYJ2022053014060000182000021No. 81991220308 &amp; No. U20A20396ZNLH201905No. ZNLH201905 and No. ZNLH202203No. 82000021Li YQin LChen JLiu MRen YChen LXiong CCai KHu BXu JHou WfalsePathogenic <i>Leptospira</i> Infections in Hubei Province, Central China.Leptospirosis is an important zoonosis that is caused by pathogenic Leptospira, which is considered to be a re-emerging infectious disease in many countries. Rodents are the most important reservoirs for both human and animal infection. An epidemiological survey of pathogenic Leptospira in rodents is important for the prevention and control of leptospirosis. In this study, a total of 964 rodents were captured from six cities in Hubei Province, and two pathogenic Leptospira species (L. interrogans and L. borgpetersenii) were detected using nested PCR with an overall prevalence of 4.8%. L. interrogans was distributed in five sampling sites, which may be the dominant species of pathogenic Leptospira in Hubei Province. In addition, Rattus norvegicus showed a relatively high infection rate, whi2022-01-01T00:00:00Z2022 Dec2026-04-08T11:23:30.154Z2025-02-19T04:45:44.742ZS-EPMC98652943667739210.3390/microorganisms11010099