{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(1)"],"submitter":["Khan BA"],"pubmed_abstract":["New <i>S</i>-alkyl phthalimide <b>5a</b>-<b>f</b> and <i>S</i>-benzyl <b>6a</b>-<b>d</b> analogs of 5-(2-phenylquinolin-4-yl)-1,3,4-oxadiazole-2-thiol (<b>4</b>) were prepared by reacting <b>4</b> with <i>N</i>-bromoalkylphthalimide and CF<sub>3</sub>-substituted benzyl bromides in excellent yields. Spectroscopic techniques were employed to elucidate the structures of the synthesized molecules. The inhibition activity of newly synthesized molecules toward MAO-A, MAO-B, and AChE enzymes, was also assessed. All these compounds showed activity in the submicromolar range against all enzymes. Compounds <b>5a</b> and <b>5f</b> were found to be the most potent compounds against MAO-A (IC<sub>50</sub> = 0.91 ± 0.15 nM) and MAO-B (IC<sub>50</sub> = 0.84 ± 0.06 nM), while compound <b>5c</b> showed t"],"journal":["Pharmaceuticals (Basel, Switzerland)"],"pagination":["11"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9865589"],"repository":["biostudies-literature"],"pubmed_title":["Synthesis and Evaluation of Novel <i>S</i>-alkyl Phthalimide- and <i>S</i>-benzyl-oxadiazole-quinoline Hybrids as Inhibitors of Monoamine Oxidase and Acetylcholinesterase."],"pmcid":["PMC9865589"],"pubmed_authors":["Khan BA","Shawky AM","Iqbal J","Ibrahim MAA","Alqahtani AM","Gabr GA","Sidhom PA","Hamdani SS","Jalil S","Ejaz SA"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis and Evaluation of Novel <i>S</i>-alkyl Phthalimide- and <i>S</i>-benzyl-oxadiazole-quinoline Hybrids as Inhibitors of Monoamine Oxidase and Acetylcholinesterase.","description":"New <i>S</i>-alkyl phthalimide <b>5a</b>-<b>f</b> and <i>S</i>-benzyl <b>6a</b>-<b>d</b> analogs of 5-(2-phenylquinolin-4-yl)-1,3,4-oxadiazole-2-thiol (<b>4</b>) were prepared by reacting <b>4</b> with <i>N</i>-bromoalkylphthalimide and CF<sub>3</sub>-substituted benzyl bromides in excellent yields. Spectroscopic techniques were employed to elucidate the structures of the synthesized molecules. The inhibition activity of newly synthesized molecules toward MAO-A, MAO-B, and AChE enzymes, was also assessed. All these compounds showed activity in the submicromolar range against all enzymes. Compounds <b>5a</b> and <b>5f</b> were found to be the most potent compounds against MAO-A (IC<sub>50</sub> = 0.91 ± 0.15 nM) and MAO-B (IC<sub>50</sub> = 0.84 ± 0.06 nM), while compound <b>5c</b> showed t","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2026-04-08T14:07:41.009Z","creation":"2024-10-16T17:13:37.836Z"},"accession":"S-EPMC9865589","cross_references":{"pubmed":["36678507"],"doi":["10.3390/ph16010011"]}}