biostudies-literatureJiapaer ZTianshan Youth Foundation of XinjiangNational Natural Science Foundation of ChinaMassachusetts General Hospital Institutional fund155https://www.ebi.ac.uk/biostudies/studies/S-EPMC9865796biostudies-literatureUnknown15(1)Cardiovascular diseases (CVDs) remain the world's leading cause of death despite the best available healthcare and therapy. Emerging as a key mediator of intercellular and inter-organ communication in CVD pathogenesis, extracellular vesicles (EVs) are a heterogeneous group of membrane-enclosed nano-sized vesicles released by virtually all cells, of which their RNA cargo, especially non-coding RNAs (ncRNA), has been increasingly recognized as a promising diagnostic and therapeutic target. Recent evidence shows that ncRNAs, such as small ncRNAs, circular RNAs, and long ncRNAs, can be selectively sorted into EVs or other non-vesicular carriers and modulate various biological processes in recipient cells. In this review, we summarize recent advances in the literature regarding the origin, extrPharmaceuticsExtracellular Non-Coding RNAs in Cardiovascular Diseases.PMC9865796819002872198632019Q06682205088Yang XSun LLi GLi CLei JZhang LChatterjee EJiapaer ZfalseExtracellular Non-Coding RNAs in Cardiovascular Diseases.Cardiovascular diseases (CVDs) remain the world's leading cause of death despite the best available healthcare and therapy. Emerging as a key mediator of intercellular and inter-organ communication in CVD pathogenesis, extracellular vesicles (EVs) are a heterogeneous group of membrane-enclosed nano-sized vesicles released by virtually all cells, of which their RNA cargo, especially non-coding RNAs (ncRNA), has been increasingly recognized as a promising diagnostic and therapeutic target. Recent evidence shows that ncRNAs, such as small ncRNAs, circular RNAs, and long ncRNAs, can be selectively sorted into EVs or other non-vesicular carriers and modulate various biological processes in recipient cells. In this review, we summarize recent advances in the literature regarding the origin, extr2023-01-01T00:00:00Z2023 Jan2025-04-04T10:21:26.095Z2025-02-19T00:12:52.752ZS-EPMC98657963667878410.3390/pharmaceutics15010155