{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jmel MA"],"funding":["National Institutes of Health","NIH HHS"],"pagination":["1556"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9865953"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(2)"],"pubmed_abstract":["Kunitz domain-containing proteins are ubiquitous serine protease inhibitors with promising therapeutic potential. They target key proteases involved in major cellular processes such as inflammation or hemostasis through competitive inhibition in a substrate-like manner. Protease inhibitors from the Kunitz superfamily have a low molecular weight (18-24 kDa) and are characterized by the presence of one or more Kunitz motifs consisting of α-helices and antiparallel β-sheets stabilized by three disulfide bonds. Kunitz-type inhibitors are an important fraction of the protease inhibitors found in tick saliva. Their roles in inhibiting and/or suppressing host homeostatic responses continue to be shown to be additive or synergistic with other protease inhibitors such as cystatins or serpins, ultim"],"journal":["International journal of molecular sciences"],"pubmed_title":["Tick Salivary Kunitz-Type Inhibitors: Targeting Host Hemostasis and Immunity to Mediate Successful Blood Feeding."],"pmcid":["PMC9865953"],"funding_grant_id":["Z01 AI001337-01"],"pubmed_authors":["Araujo RN","Jmel MA","Tirloni L","Sa-Nunes A","Voet H","Kotsyfakis M"],"additional_accession":[]},"is_claimable":false,"name":"Tick Salivary Kunitz-Type Inhibitors: Targeting Host Hemostasis and Immunity to Mediate Successful Blood Feeding.","description":"Kunitz domain-containing proteins are ubiquitous serine protease inhibitors with promising therapeutic potential. They target key proteases involved in major cellular processes such as inflammation or hemostasis through competitive inhibition in a substrate-like manner. Protease inhibitors from the Kunitz superfamily have a low molecular weight (18-24 kDa) and are characterized by the presence of one or more Kunitz motifs consisting of α-helices and antiparallel β-sheets stabilized by three disulfide bonds. Kunitz-type inhibitors are an important fraction of the protease inhibitors found in tick saliva. Their roles in inhibiting and/or suppressing host homeostatic responses continue to be shown to be additive or synergistic with other protease inhibitors such as cystatins or serpins, ultim","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-04T10:20:00.562Z","creation":"2025-02-19T00:12:50.808Z"},"accession":"S-EPMC9865953","cross_references":{"pubmed":["36675071"],"doi":["10.3390/ijms24021556"]}}