{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tian Y"],"funding":["Sheng Yin","Rong Pu","Guihua Tang"],"pagination":["511"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9867043"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(2)"],"pubmed_abstract":["Glochidpurnoids A and B (<b>1</b> and <b>2</b>), two new coumaroyl or feruloyl oleananes, along with 17 known triterpenoids (<b>3</b>-<b>19</b>) were obtained from the stems and twigs of <i>Glochidion puberum</i>. Their structures were elucidated by extensive spectroscopic data analyses, chemical methods, and single crystal X-ray diffraction. All compounds were screened for cytotoxicity against the colorectal cancer cell line HCT-116, and <b>2</b>, <b>3</b>, <b>5</b>, <b>6</b>, <b>11</b>, and <b>17</b> showed remarkable inhibitory activities (IC<sub>50</sub>: 0.80-2.99 μM), being more active than the positive control 5-fluorouracil (5-FU). The mechanistic study of <b>2</b>, the most potent compound, showed that it could induce endoplasmic reticulum (ER) stress-mediated apoptosis and improv"],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Glochodpurnoid B from <i>Glochidion puberum</i> Induces Endoplasmic Reticulum Stress-Mediated Apoptosis in Colorectal Cancer Cells."],"pmcid":["PMC9867043"],"funding_grant_id":["2021B1515140062","82273804","81973195","SML2021SP301","SZBL2021080601007","81973203"],"pubmed_authors":["Pu R","Yuan F","Huang D","Huang Y","Yin S","Tian Y","Yin A","Tang G","Fan R","Yin Z"],"additional_accession":[]},"is_claimable":false,"name":"Glochodpurnoid B from <i>Glochidion puberum</i> Induces Endoplasmic Reticulum Stress-Mediated Apoptosis in Colorectal Cancer Cells.","description":"Glochidpurnoids A and B (<b>1</b> and <b>2</b>), two new coumaroyl or feruloyl oleananes, along with 17 known triterpenoids (<b>3</b>-<b>19</b>) were obtained from the stems and twigs of <i>Glochidion puberum</i>. Their structures were elucidated by extensive spectroscopic data analyses, chemical methods, and single crystal X-ray diffraction. All compounds were screened for cytotoxicity against the colorectal cancer cell line HCT-116, and <b>2</b>, <b>3</b>, <b>5</b>, <b>6</b>, <b>11</b>, and <b>17</b> showed remarkable inhibitory activities (IC<sub>50</sub>: 0.80-2.99 μM), being more active than the positive control 5-fluorouracil (5-FU). The mechanistic study of <b>2</b>, the most potent compound, showed that it could induce endoplasmic reticulum (ER) stress-mediated apoptosis and improv","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-26T00:36:51.623Z","creation":"2025-02-19T03:00:18.283Z"},"accession":"S-EPMC9867043","cross_references":{"pubmed":["36677570"],"doi":["10.3390/molecules28020511"]}}