biostudies-literatureUnknown54(1)Zwolinska WUniwersytet Medyczny im. Karola Marcinkowskiego w PoznaniuDespite the significant prevalence of Major Depressive Disorder in the pediatric population, the pathophysiology of this condition remains unclear, and the treatment outcomes poor. Investigating tools that might aid in diagnosing and treating early-onset depression seems essential in improving the prognosis of the future disease course. Recent studies have focused on searching for biomarkers that constitute biochemical indicators of MDD susceptibility, diagnosis, or treatment outcome. In comparison to increasing evidence of possible biomarkers in adult depression, the studies investigating this subject in the youth population are lacking. This narrative review aims to summarize research on molecular and biochemical biomarkers in child and adolescent depression in order to advocate future dChild psychiatry and human development266-281https://www.ebi.ac.uk/biostudies/studies/S-EPMC9867683biostudies-literatureBiomarkers in Child and Adolescent Depression.PMC9867683Slopien ADmitrzak-Weglarz MZwolinska WfalseBiomarkers in Child and Adolescent Depression.Despite the significant prevalence of Major Depressive Disorder in the pediatric population, the pathophysiology of this condition remains unclear, and the treatment outcomes poor. Investigating tools that might aid in diagnosing and treating early-onset depression seems essential in improving the prognosis of the future disease course. Recent studies have focused on searching for biomarkers that constitute biochemical indicators of MDD susceptibility, diagnosis, or treatment outcome. In comparison to increasing evidence of possible biomarkers in adult depression, the studies investigating this subject in the youth population are lacking. This narrative review aims to summarize research on molecular and biochemical biomarkers in child and adolescent depression in order to advocate future d2023-01-01T00:00:00Z2023 Feb2025-04-04T10:19:55.43Z2025-02-19T00:12:36.403ZS-EPMC98676833459020110.1007/s10578-021-01246-y