biostudies-literatureCai JNanjing Medical Science and Technology Development FundNational Natural Science Foundation of ChinaJiangsu Commission of Health15https://www.ebi.ac.uk/biostudies/studies/S-EPMC9867863biostudies-literatureUnknown13(1)<h4>Background</h4>Medulloblastoma (MB) is one of the most common malignant pediatric brain tumors. Metastasis and relapse are the leading causes of death in MB patients. The initiation of the SHH subgroup of MB (SHH-MB) is due to the aberrant activation of Sonic Hedgehog (Shh) signaling. However, the mechanisms for its metastasis are still unknown.<h4>Results</h4>AMP-dependent protein kinase (AMPK) restrains the activation of Shh signaling pathway, thereby impeding the proliferation of SHH-MB cells. More importantly, AMPK also hinders the growth and metastasis of SHH-MB cells by regulating NF-κB signaling pathway. Furthermore, Vismodegib and TPCA-1, which block the Shh and NF-κB pathways, respectively, synergistically restrained the growth, migration, and invasion of SHH-MB cells.<h4>ConcCell & bioscienceAMPK attenuates SHH subgroup medulloblastoma growth and metastasis by inhibiting NF-κB activation.PMC986786382173291YKK21148Z202003582172629Cheng SYYue SHe JCai JYang XYao YLi TYu TWang XPu XLiu CWang YAi ZfalseAMPK attenuates SHH subgroup medulloblastoma growth and metastasis by inhibiting NF-κB activation.<h4>Background</h4>Medulloblastoma (MB) is one of the most common malignant pediatric brain tumors. Metastasis and relapse are the leading causes of death in MB patients. The initiation of the SHH subgroup of MB (SHH-MB) is due to the aberrant activation of Sonic Hedgehog (Shh) signaling. However, the mechanisms for its metastasis are still unknown.<h4>Results</h4>AMP-dependent protein kinase (AMPK) restrains the activation of Shh signaling pathway, thereby impeding the proliferation of SHH-MB cells. More importantly, AMPK also hinders the growth and metastasis of SHH-MB cells by regulating NF-κB signaling pathway. Furthermore, Vismodegib and TPCA-1, which block the Shh and NF-κB pathways, respectively, synergistically restrained the growth, migration, and invasion of SHH-MB cells.<h4>Conc2023-01-01T00:00:00Z2023 Jan2026-04-08T11:22:19.493Z2025-02-19T04:45:42.996ZS-EPMC98678633668306410.1186/s13578-023-00963-2