{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Nicolas M"],"funding":["Ministère des Affaires Etrangères"],"pubmed_abstract":["<b>Introduction:</b> Formerly named <i>Plectranthus</i> <i>forsteri</i>, <i>Coleus forsteri</i> (Benth.) A.J.Paton, 2019 is a Lamiaceae traditionally used to treat flu-like symptoms and shock-related ecchymosis, especially in the Pacific region. Few studies investigated chemical composition and anti-inflammatory potential of this plant. <b>Method:</b> Herein, we investigated anti-inflammatory potential of <i>C. forsteri</i> ethanolic (ePE) and cyclohexane (cPE) plant extract on LPS-induced human macrophages models and quantified cytokines and quinolinic acid (QUIN) as inflammatory markers. <b>Results:</b> Our results show that extract of ePE and cPE significantly inhibit inflammatory cytokine IL-6 and TNF-α induced by LPS on PMA-derived THP-1 macrophages. QUIN production is also diminished"],"journal":["Frontiers in pharmacology"],"pagination":["1081310"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9868419"],"repository":["biostudies-literature"],"pubmed_title":["Anti-inflammatory activities of <i>Coleus forsteri</i> (formerly <i>Plectranthus forsteri</i>) extracts on human macrophages and chemical characterization."],"pmcid":["PMC9868419"],"pubmed_authors":["Matsui M","Chow S","Nicolas M","Nour M","Antheaume C","Huet K","Guillemin GJ","Lasalo M","Hnawia E"],"additional_accession":[]},"is_claimable":false,"name":"Anti-inflammatory activities of <i>Coleus forsteri</i> (formerly <i>Plectranthus forsteri</i>) extracts on human macrophages and chemical characterization.","description":"<b>Introduction:</b> Formerly named <i>Plectranthus</i> <i>forsteri</i>, <i>Coleus forsteri</i> (Benth.) A.J.Paton, 2019 is a Lamiaceae traditionally used to treat flu-like symptoms and shock-related ecchymosis, especially in the Pacific region. Few studies investigated chemical composition and anti-inflammatory potential of this plant. <b>Method:</b> Herein, we investigated anti-inflammatory potential of <i>C. forsteri</i> ethanolic (ePE) and cyclohexane (cPE) plant extract on LPS-induced human macrophages models and quantified cytokines and quinolinic acid (QUIN) as inflammatory markers. <b>Results:</b> Our results show that extract of ePE and cPE significantly inhibit inflammatory cytokine IL-6 and TNF-α induced by LPS on PMA-derived THP-1 macrophages. QUIN production is also diminished","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-03-16T08:11:54.971Z","creation":"2025-04-04T19:48:08.731Z"},"accession":"S-EPMC9868419","cross_references":{"pubmed":["36699063"],"doi":["10.3389/fphar.2022.1081310"]}}