biostudies-literatureUnknown13Nicolas MMinistère des Affaires Etrangères<b>Introduction:</b> Formerly named <i>Plectranthus</i> <i>forsteri</i>, <i>Coleus forsteri</i> (Benth.) A.J.Paton, 2019 is a Lamiaceae traditionally used to treat flu-like symptoms and shock-related ecchymosis, especially in the Pacific region. Few studies investigated chemical composition and anti-inflammatory potential of this plant. <b>Method:</b> Herein, we investigated anti-inflammatory potential of <i>C. forsteri</i> ethanolic (ePE) and cyclohexane (cPE) plant extract on LPS-induced human macrophages models and quantified cytokines and quinolinic acid (QUIN) as inflammatory markers. <b>Results:</b> Our results show that extract of ePE and cPE significantly inhibit inflammatory cytokine IL-6 and TNF-α induced by LPS on PMA-derived THP-1 macrophages. QUIN production is also diminishedFrontiers in pharmacology1081310https://www.ebi.ac.uk/biostudies/studies/S-EPMC9868419biostudies-literatureAnti-inflammatory activities of <i>Coleus forsteri</i> (formerly <i>Plectranthus forsteri</i>) extracts on human macrophages and chemical characterization.PMC9868419Matsui MChow SNicolas MNour MAntheaume CHuet KGuillemin GJLasalo MHnawia EfalseAnti-inflammatory activities of <i>Coleus forsteri</i> (formerly <i>Plectranthus forsteri</i>) extracts on human macrophages and chemical characterization.<b>Introduction:</b> Formerly named <i>Plectranthus</i> <i>forsteri</i>, <i>Coleus forsteri</i> (Benth.) A.J.Paton, 2019 is a Lamiaceae traditionally used to treat flu-like symptoms and shock-related ecchymosis, especially in the Pacific region. Few studies investigated chemical composition and anti-inflammatory potential of this plant. <b>Method:</b> Herein, we investigated anti-inflammatory potential of <i>C. forsteri</i> ethanolic (ePE) and cyclohexane (cPE) plant extract on LPS-induced human macrophages models and quantified cytokines and quinolinic acid (QUIN) as inflammatory markers. <b>Results:</b> Our results show that extract of ePE and cPE significantly inhibit inflammatory cytokine IL-6 and TNF-α induced by LPS on PMA-derived THP-1 macrophages. QUIN production is also diminished2022-01-01T00:00:00Z20222026-03-16T08:11:54.971Z2025-04-04T19:48:08.731ZS-EPMC98684193669906310.3389/fphar.2022.1081310